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Chapter – 4 Studies on different types of reactions….. chemistry research to undertake the synthesis of pyrazole-4-carboxldehyde derivatives using Vilsmeier-Haack (VH). 17-19 The study is particularly aimed at developing a one-pot synthesis of pyrazole-4-carboxaldehyde oximes starting from acetophenone phenylhydrazones. Department of Chemistry, Saurashtra University, Rajkot – 360 005 189
Chapter – 4 Studies on different types of reactions….. 4.2 INTRODUCTION TO OXINDOLE Oxindole (1, 3-dihydro-2H-indol-2-one; C8H7NO) is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a sixmembered benzene ring fused to a five-membered nitrogen-containing ring. The compound's structure is based on the indoline structure but where a carbonyl is situated at the 2-position of the five-membered ring. 4.2.1 PHYSICAL PROPERTIES OF OXINDOLE Oxindole crystallizes from water in colourless needles melting at 126- 127°C. The substance boils at 195°C at 17 mm a and at 227°C at 73 mm. 21 It is soluble in hot water, alchohol, benzene, ether and acetic acid. It is more soluble in alkaline solutions than in water. The heat of combustion at constant volume has been found to be about 950.5 kg.-cal./mole. b The chemistry of indoles especially that of oxindole derivatives dates back to 134 years old when first Baeyer 20 published the results of his researches on the reaction of isatin. In addition to isatide, which had been obtained previously by Laurent 21-23 and by Erdmann, 24 Baeyer obtained dioxindole (C8H7NO2) by the further reduction of which oxindole was prepared. Baeyer established the constitution of oxindole as the lactam of 2aminophenylaceticacid through its synthesis by the reduction of 2- a A. Waul and P. Bagard; Compt. rend., 1910, 149, 132. b M. Berthelomt and G. Andre; Compt. rend., 1899, 128, 970. 5 6 4 7 Department of Chemistry, Saurashtra University, Rajkot – 360 005 190 3 N H 1 Fig. 4.1 2 O
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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