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Chapter – 4 Studies on different types of reactions…..
1 Anschutz method 137
2 Pauli Lockemann synthesis 138
3 Sonn's synthesis 139
4 Mentzer's synthesis 140
5 Robertson synthesis 141
6 Ziegler and Junek method 142
7 Garden's method 143
8 Shah, Bose and Shah's method 144
9 Kaneyuki method 145
10 Resplandy's method 146
11 Jain, Rohatagi and Sheshadri's method 147
12 Shah, Bhatt and Thakor's method 148
Shah and co-workers 144, 148 have prepared 4-hydroxy coumarin
derivatives in good yield by condentation of different phenols with malonic
acid in the presence of zinc chloride and phosphorous oxychloride. The
method is useful as single step preparation of 4-hydroxy coumarin derivatives
substituted in benzenoid part.
Recently many researchers 149-180 have reported synthetic strategies
for 4-hydroxy coumarin.
4.3.2 BIOLOGICAL ACTIVITIES ASSOCIATED WITH 4-
HYDROXYCOUMARIN DERIVATIVES
Numerous biological activities have been associated with simple
coumarins and its analogues. Among them, antimicrobial, antiviral, anticancer,
enzyme inhibition, anti-inflammatory, antioxidant, anticoagulant and effect on
central nervous system are most prominent. Coumarin nucleus possesses
diversified biological activities that can be briefly summarized as under:
1 Antimicrobial and Molluscicidal 181-202
2 Antiviral 203-207
3 Anticancer 208-218
4 As Enzyme Inhibition 219-224
Department of Chemistry, Saurashtra University, Rajkot – 360 005 200