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Chapter – 4 Studies on different types of reactions….. and 4-hydroxycoumarin was refluxed into methanol under acidic condition to give rise to the expected product. 4.14 CONCLUSION 2-Indolinone derivatives have recently been established as an anti cancer compounds and more specifically as tyrosine kinase inhibitors (SU5416, SU5614, SU6668, SU6597, SU6663 and SU6561) that block kit activation and growth of small cell in lung cancer. Moreover Virsodia et. al. a reported the anticancer evaluation results of the arylidine products of 1-(2, 6dichlorophenyl)-2-indolinone. Biological importance of such scaffolds inspired us to prepare new indolinone derivatives and to carry out their anticancer evaluation. 4-hydroxycoumarin is a versatile scaffold and is being consistently used as a building block in organic chemistry as well as in heterocyclic chemistry for the synthesis of different heterocycles. The synthetic versatility of 4-hydroxycoumarin has led to the extensive use of this compound in organic synthesis. 4-hydroxy coumarin shows diversified chemical reactivity and biological profile. Thus it was of interest to study the biological activities of newly synthesized coumarin derivatives. Department of Chemistry, Saurashtra University, Rajkot – 360 005 253
Chapter – 4 Studies on different types of reactions….. 4.15 SPECTRAL REPRESENTATION OF SYNTHESIZED COMPOUNDS 4.15.1 Mass Spectrum of DNJ-705 4.15.2 IR Spectrum of DNJ-705 120 %T 100 80 60 40 20 4000 3500 DNJ-705 3076.56 3057.27 3000 2500 2000 1700.31 1697.41 1620.26 1602.90 1750 MW : 542 g/m 500 1/cm Department of Chemistry, Saurashtra University, Rajkot – 360 005 254 1564.32 1523.82 1493.92 1500 1461.13 1437.02 1384.94 1330.93 1214.23 1176.62 1250 Cl 1154.43 Cl 1098.50 N 1051.24 1012.66 954.80 888.25 1000 O Cl 834.24 N N 784.09 746.48 685.72 750 633.64 556.48 516.94 448.46
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Saurashtra University Re - Accredit
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Statement under O. Ph. D. 7 of Saur
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ACKNOWLEDGEMENT It is a moment of g
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Jignesh Lunagariya, Hitesh Sarvaiya
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CONTENT Content General Remarks 6 A
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Content 3.2 Reaction scheme 149 3.3
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5.14 Conclusion 313 5.15 Spectral r
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MF Molecular Formula MW Molecular W
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GABA Gamma Amino Butyric Acid MES M
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PART - A STUDIES ON 2-METHYL INDOLI
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Part-A Studies on 2-methyl indoline
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CHAPTER - 1 PREPARATION AND YIELD O
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Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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