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Part – B Studies on isatin derivatives…..
Sriram et. al. 255 synthesized some 7-substituted ciprofloxacin
derivatives by Mannich reaction using ciprofloxacin, formaldehyde and
differently substituted isatin and its derivatives. (Fig. B.1.26)
Mohamed et. al. 256 prepared N-Mannich bases of phthalimide, isatin,
5-fluoroisatin, 5-chloroisatin, diphenylamine and succinimide using
formaldehyde and 8-Hydroxyquinoline to give title compounds. (Fig. B.1.27)
N
OH
Fig. B.1.26
CH 2 N
Ravichandran et. al. 257 prepared a series of 2, 3-dihydro-2-oxo-1, 3disubstituted
indoles by the reaction of 2, 3-dihydro-2-oxo-3-substituted
indoles with 2-[(2, 6-dichlorophenyl) amino] phenylacetic acid in the presence
of formaldehyde. The title compounds were synthesized in two steps. First
step consists condensation of substituted amine and isatin while second step
involves Mannich reaction using formaldehyde and 2-[(2, 6-dichlorophenyl)
amino] phenylacetic acid. (Fig. B.1.28)
Where, R = 4-chloroaniline, 4-amino benzene sulphonamide, 4-amino
benzoic acid, 2-amino benzoic acid, Phenyl hydrazine.
Department of Chemistry, Saurashtra University, Rajkot-360 005 129
O
Fig. B.1.27
O I