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Part-A Studies on 2-methyl indoline derivatives….. 122 H. J. Kabbe, H. P. Krause and R. Sitt; Eur. Pat. Appl., 28765, 1981. 123 J. Bermudez, S. Dabbs, K. A. Joiner and F. D. King, J. Med. Chem., 1990, 33(7), 1929. 124 P. Spang, P. Neumann and H. Trauth; Eur. Pat. Appl., 399278, 1990. 125 K. C. Nicolaou, A. J. Roecker, J. A. Pfefferkorn and G.-Q. Cao; J. Am. Chem. Soc., 2000, 122(12), 2966. 126 M. J. Ellis and M. F. G. Stevens; J. Chem. Soc., 2001, 23, 3180. 127 K. C. Nicolaou, A. J. Roecker, R. Hughes, R. van Summeren and J. A. Pfefferkorn, N. Winssinger; Bioorg. & Med. Chem., 2003, 11(3), 465. 128 H. Zhao, X. Zhang, K. Hodgetts, A. Thurkauf, J. Hammer, J. Chandrasekhar, A. Kieltyka, R. Brodbeck, S. Rachwal, R. Primus and C. Manly; Bioorg. & Med. Chem. Lett., 2003, 13(4), 701. 129 I. V. Tyunova, S. I. Filimonov, M. U. Solovjev, K. V. Balakin, A. V. Skorenko and M. V. Dorogov; Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya, 2003, 46(7), 77. 130 P. F. Bordon and J. L. Haesslein; Fr. Demande, 2851248, 2004. 131 J. E. Gonzales III, A. P. Termin, E. Martinborough, N. Zimmerman; PCT Int. Appl., 2005013914, 2005. 132 H. Dehmlow, B. Kuhn, N. Panday, H. Ratni, T. Schulz-Gasch and M. B. Wright; U.S. Pat. Appl. Publ., 2005245515, 2005. 133 Y. Okada, T. Minami, M. Miyamoto, T. Otaguro, S. Sawasaki and J. Ichikawa; Heteroatom Chemistry, 1995, 6(3), 195. 134 B. Orsat, P. B. Alper, W. Moree, C.-P. Mak and C.-H. Wong; J. Am. Chem. Soc., 1996, 118(3), 712. 135 V. P. Krasnov, G. L. Levit, I. N. Andreeva, A. N. Grishakov, V. N. Charushin and O. N. Chupakhin; Mendeleev Communications, 2002, 1, 27. 136 O. Benali, M. A. Miranda, R. Tormos and S. Gil; J. Org. Chem., 2002, 67(22), 7915. 137 H. Zhao, X. He, A. Thurkauf, D. Hoffman, A. Kieltyka, R. Brodbeck, R. Primus and J. W. F. Wasley; Bioorg. & Med. Chem. Lett., 2002, 12(21), 3111. 138 F. Thorstensson, I. Kvarnstroem, D. Musil, I. Nilsson and B. Samuelsson; J. Med. Chem., 2003, 46(7), 1165. 139 V. P. Krasnov, G. L. Levit, I. M. Bukrina, I. N. Andreeva, L. Sh. Sadretdinova, M. A. Korolyova, M. I. Kodess, V. N. Charushin and O. N. Chupakhin; Tetrahedron: Asymmetry, 2003, 14(14), 1985. 140 V. P. Krasnov, G. L. Levit, M. I. Kodess, V. N. Charushin and O. N. Chupakhin; Tetrahedron: Asymmetry, 2004, 15(5), 859. 141 C. Y. Kim, P. E. Mahaney, E. J. Trybulski, P. Zhang, E. A. Terefenko, C. C. Mccomas, M. A. Marella, R. D. Coghlan, G. D. Heffernan, S. T. Cohn, A. T.Vu, J. P. Sabatucci and F. Ye; U.S. Pat. Appl. Publ., 2005222148, 2005. Department of Chemistry, Saurashtra University, Rajkot – 360 005 31
Part-A Studies on 2-methyl indoline derivatives….. 142 Y. Y. Shalygina, K. V. Balakin, S. A. Ivanovsky, I. K. Proskurina, M. V. Dorogov and S. V. Ryabinina; Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya, 2005, 48(1), 66. 143 V. Gotor-Fernandez, P. Fernandez-Torres and V. Gotor; Tetrahedron: Asymmetry, 2006, 17(17), 2558. 144 R. Abonia, A. Albornoz, B. Insuasty, J. Quiroga, H. Meier, A. Hormaza, M. Nogueras, A. Sanchez, J. Cobo and J. N. Low; Tetrahedron, 2001, 57(23), 4933. Department of Chemistry, Saurashtra University, Rajkot – 360 005 32
Page 1 and 2: Saurashtra University Re - Accredit
Page 3 and 4: Statement under O. Ph. D. 7 of Saur
Page 6 and 7: ACKNOWLEDGEMENT It is a moment of g
Page 8 and 9: Jignesh Lunagariya, Hitesh Sarvaiya
Page 10 and 11: CONTENT Content General Remarks 6 A
Page 12 and 13: Content 3.2 Reaction scheme 149 3.3
Page 14 and 15: 5.14 Conclusion 313 5.15 Spectral r
Page 16 and 17: MF Molecular Formula MW Molecular W
Page 18 and 19: GABA Gamma Amino Butyric Acid MES M
Page 20 and 21: PART - A STUDIES ON 2-METHYL INDOLI
Page 22 and 23: Part-A Studies on 2-methyl indoline
Page 42 and 43: CHAPTER - 1 PREPARATION AND YIELD O
Page 44 and 45: Chapter - 1 Preparation and Yield o
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Chapter - 2 Microwave assisted simp
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Part - B Studies on isatin derivati
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CHAPTER - 3 PREPARATION OF SMALL LI
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Chapter - 3 Preparation of small li
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CHAPTER - 4 STUDIES ON DIFFERENT TY
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Chapter - 4 Studies on different ty
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Chapter - 5 Synthesis and Character
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Chapter - 6 Biological evaluation o
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Summary Synthesis and biological pr
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Summary Synthesis and biological pr
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Conferences / Seminar / Workshop At
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