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Part-A Studies on 2-methyl indoline derivatives…..
Fig. A.10
Ellis et. al. 126 replaced hydrogen atom of secondary amine in 2-methyl
indoline with 1-bromo-9-chloroacridine using HMPT and carried out cytotoxic
activity against 60 human cancer cell lines.
Furthermore using a polymer-bound selenenyl bromide resin, o-allyl
and o-prenyl anilines were cycloloaded to afford a series of solid-supported
indoline and indole scaffolds. 127 These scaffolds were then functionalized and
cleaved via four distinct methods, namely traceless reduction, radical
cyclization, radical rearrangement, and oxidative elimination, to afford 2methyl
indolines, e.g. (1), polycyclic indolines, e.g. (2), 2-methyl indoles, e.g.
(3), and 2-propenyl indolines, e.g. (4), respectively. Numbers of small
combinatorial libraries of compounds reminiscent of certain designed ligands
of biological interest were constructed demonstrating the potential utility of the
developed methodology to chemical and biological studies and the drug
discovery process. (Fig. A.11)
Fig. A.11
Department of Chemistry, Saurashtra University, Rajkot – 360 005 23