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Chapter – 2 Microwave assisted simple and fast…..
2.2 REACTION SCHEMES
2.2.1 PREPARATION OF 2-METHYL-1-[3-(SUBSTITUTED-1-YL) PROPYL]
INDOLINE
STEP – 1
a
Br Cl Cl N
Reagents / Reaction Condition (a): Secondary amines, Toluene/ 75°C, 4
hours.
STEP – 2
R 1
Reagents / Reaction Condition (b): 2-methyl indoline, K2CO3, DMF/ MW, 480
W.
2.2.2 PREPARATION OF 2-METHYL-1-[2-(SUBSTITUTED-1-YL)-2-
OXOETHYL] INDOLINE
STEP – 1
Cl
N
R 2
O
Cl
Cl
b
c
Reagents / Reaction Condition (c): Secondary amines, Benzene, TEA/ 0-5°C,
12 hours, stirring.
Department of Chemistry, Saurashtra University, Rajkot – 360 005 75
Cl
R 1
N
R 2
N
R 2
N
R 1
CH 3
R 1
O R 2