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Part – B Studies on isatin derivatives…..
Mesropyan et. al. 251 synthesized new N-derivatives of isatin by treating
ethyl- chloroacetate, N-(2-chloroethyl) morpholine, and 1, 4bis(chloromethyl)benzene
with isatin sodium salt. N-derivatives of isatin and
5-bromoisatin were also prepared by Mannich reaction. (Fig. B.1.21)
Mogilaiah et. al. 252 disclosed a conventional method for the
preparation of the Mannich base of 3-[3-(p-chlorophenyl)-1, 8-naphthyridin-2ylhydrazono]-2-indolinones
using formaldehyde and piperidine. The starting
material was prepared by the condensation of 2-hydrazino-3-(p-chlorophenyl)-
1, 8-naphthyridine and 3-phenylimino-2-indolinones. (Fig. B.1.22)
Fig. B.1.22
Fig. B.1.21
NH
N
Yogeeswari et. al. 253 synthesized Mannich bases of gatifloxacin by
reacting them with formaldehyde and several isatin derivatives. (Fig. B.1.23)
Sriram et. al. 254 reported the synthesis of various aminopyrimidinimino
isatin derivatives which was achieved in two steps. First step consists
condensation of 5-bromo isatin and 5-(3, 4, 5-trimethoxybenzyl) pyrimidine-
2,4-diamine followed by Mannich reaction using formaldehyde and various
secondary amines (R'). (Fig. B.1.24)
Department of Chemistry, Saurashtra University, Rajkot-360 005 127
Cl
O
N
N