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Chapter – 4 Studies on different types of reactions…..
proteins. It has now been found that certain novel chalcones, chalcone
derivatives and chalcone analogues, in particular ones in which the phenyl
ring at the 1 st position is substituted or replaced by the rings containing one or
more heteroatoms, possess greater antiproliferation activity both on sensitive
cancer cells or on cells which are resistant to common chemotherapeutic
drugs, including the latest generation of anti-neoplastic agents, pacitaxel and
docetaxel.
In recent patent literature, compounds of the general formula shown in
Fig. 4.10 are a pharmaceutically acceptable salt or solvate there of wherein Ar
represents a substituted or unsubstituted, (preferably aromatic), carbocycilc or
heterocyclic group, said carbocyclic or heterocyclic group containing from 5 to
10 ring atoms, said ring atoms forming one or two rings, wherein each ring
contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S,
any substituents on the Ar group being independently selected from the group
consisting of: (a) Cl, (b) Br, (c) F, (d) OH, (e) NO2, (f) CF3, (g) C1-4 lower alkyl
(in particular CH3), (h) SCH3, (i) NHCOCH3, (j) N(R)(R1) wherein R and R1 are
the same or different and each represents H or lower C1-4 alkyl. (Fig. 4.10,
4.11, 4.12 and 4.13)
O
R 1
O
Fig. 4.10
Department of Chemistry, Saurashtra University, Rajkot – 360 005 202
R
COCH=CHAr