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Chapter – 5 Synthesis and Characterization…..
O O
R
N
R = H, OH, CH 3
Fig. 5.7
O O
Bardan et. al. 45 reported the synthesis of a novel series of substitutedaminocoumarins
(1) (R, R 1 = H, OH, N-arylamino) and the preliminary
evaluation of their in vitro antimicrobial activity was described. The reaction of
(1) (R = OH; R 1 = H) (Fig. 5.8) with a numbers of primary or cyclic secondary
amines afforded the corresponding aminocoumarin derivatives. Antimicrobial
screening showed that some of these novel compounds possess moderate
activity against Bacillus subtilis and Bacillus pumilus.
1
O O
In last few years, new structural classes of tyrosine kinase inhibitors
(anticancer agents) have begun to emerge which exhibit enormous
improvements in potency and specificity over prior compounds. Most of these
compounds are directed against either the epidermal growth factor (EGF) or
platelers derived growth factor (PDGF) receptor tyrosine kinease and have
Department of Chemistry, Saurashtra University, Rajkot – 360 005 285
R
Fig. 5.8
R 1
R
N