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Chapter – 2 Microwave assisted simple and fast…..
6. Four protons of morpholinyl methylene carbons (C2 & C6) gave triplet at
5.00 δ ppm.
7. Two aromatic protons of C15 and C17 methine groups gave multiplet at
6.63 δ ppm while another two aromatic protons of C16 and C18 methine
groups gave multiplet at 7.00 δ ppm.
1 H NMR spectral interpretation of 2-methyl-1-(2-oxo-2-piperidin-1-ylethyl)
indoline (DNJ-402)
1. Three most shielded protons of methyl group (C13) gave multiplet at
1.28 δ ppm. Usually these protons should show their multiplicity as
doublet due to the presence of single proton at C2, but two nitrogen
atoms are present in the molecule and thus due to their effect these
methyl protons coupled with one proton of methine group (C2) and
another two protons of methylene group (C3) and gave multiplet.
2. Four protons of two morpholinyl methylene groups attached with the
nitrogen atom gave triplet at 2.45 δ ppm, while another four protons of
rest of the two morpholinyl methylene groups attached with the oxygen
atom gave triplet at 3.73 δ ppm.
3. Two protons of C3 carbon atom splitted into two which showed singlet
for each proton at 2.62 δ ppm and at 2.83 δ ppm respectively.
4. One proton of methine group (C2) gave quartet at 3.14 δ ppm which
actually should show multiplet due to the presence of three protons of
methyl group (C13) and two protons of methylene group (C3).
5. Two protons of methylene group (C10) became deshielded due to the
two nitrogen atoms and gave singlet at 4.44 δ ppm.
6. Two aromatic protons of C6 and C8 methine groups gave multiplet at
6.63 δ ppm while another two aromatic protons of C7 and C9 methine
groups gave multiplet at 7.00 δ ppm.
1 H NMR spectral interpretation of 1-(3-morpholin-4-ylpropyl)-1H-indole-2,
3-dione (DNJ-502)
1. Two methylene protons of C8 gave multiplet at 1.28 δ ppm.
Department of Chemistry, Saurashtra University, Rajkot – 360 005 96