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Chapter – 5 Synthesis and Characterization…..
capacity to effectively suppress their targets in cells. Structures types shown
46, 47
in Fig. 5.9 were found to be most effective.
N
HN
N
As structural features of above compounds tallies with the title
compounds (i.e. 4-aryl aminocoumarins), it induced to study the possible
alteration in the activity by substituting the benzenoid part either with
electrone withdrawing group (EWG) or electrone donating group (EDG) and
also by shifting of the heterocyclic system for 4-anilinoquinazoline to other
structures like 4-anilinocoumarins.
Shan and coworkers 48-53 have synthesized the following type of 4arylaminocoumarins
shown in Fig. 5.10 and screened for anti-HIV activity
against HIV-1 (strain HTLV-IIIB / LAI) 54 and HIV-2 (strain LAV-2ROD) 55 and
antitubercular activity against M. tuberculosis H37Rv.
R
C
H 3
O
O
CH 3
Fig. 5.9
HN
O O
R = H, CH 3 , di-CH 3 , Benzo etc...
Department of Chemistry, Saurashtra University, Rajkot – 360 005 286
N
HN
R'
R' = H, CH 3 , di-CH 3 , OCH 3 , Cl, di-Cl etc...
Fig. 5.10
N
H