Download (4Mb) - Etheses - Saurashtra University

Chapter – 6 Biological evaluation of newly.....
ED50 (µg/ml) of DNJ series on Stomach, Breast, Lung cancer cell lines.
Sr. No.
Cell Lines
Representative
Compound
Hu Tu 80
(Stomach)
MDA.MB.453
(Breast)
L132
(Lung)
1 DNJ-1301 42 83 >100
2 DNJ-1302 >100 >100 >100
3 DNJ-1303 >100 78 93
4 DNJ-1304 32 33 30
5 DNJ-1305 37 52 >100
6 DNJ-1401 38 35 >100
7 DNJ-1402 49 >100 >100
8 DNJ-1403 >100 >100 >100
9 DNJ-1404 73 61 >100
10 DNJ-1405 >100 >100 74
11 DNJ-1501 >100 >100 >100
12 DNJ-1502 39 >100 >100
13 DNJ-1503 >100 81 >100
14 DNJ-1504 89 61 >100
15 DNJ-1505 30 50 84
6.2.1 RESULTS AND DISCUSSION
From the above mentioned ED50 values, it could be concluded that all
the compounds possess cytotoxic activity. All the compounds were tested in
vitro against three cancer cell lines (i.e. stomach cancer cell line-Hu Tu 80,
breast cancer cell line-MDA.MB.453 and lung cancer cell line-L132).
In case of DNJ-1301 to DNJ-1305, DNJ-1304 was found to possess
highest potency and lowest ED50 value against all the three cancer cell lines
(i.e. 32, 33 and 30 µg/ml against stomach cancer cell line-Hu Tu 80, Breast
cancer cell line-MDA.MB.453 and Lung cancer cell line-L132 respectively).
DNJ-1305 also showed good cytotoxicity activity (ED50 : 37 µg/ml) against
stomach cancer cell line-Hu Tu 80, while it showed moderate (ED50 : 52
µg/ml) cytotoxic activity against breast cancer cell line-MDA.MB.453 and it
was found less active (ED50 : >100 µg/ml) against lung cancer cell line-L132.
DNJ-1301 was found to be moderate active (ED50 : 42 µg/ml) against stomach
cancer cell line while it was found to be moderate active (ED50 : 83 µg/ml)
against breast cancer cell line and less active (ED50 : >100 µg/ml) against
Department of Chemistry, Saurashtra University, Rajkot – 360 005 335