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Chapter – 1 Preparation and Yield optimization.....
1.2.2 PREPARATION OF 2-METHYL INDOLINE N-MANNICH BASES
(1)
Reagents / Reaction Condition (d): Secondary amines, Diethylether,
Formaldehyde (37-41%), Con. HCl / RT, stirring.
(2)
N
H
N
H
CH 3
CH 3
d
e
Reagents / Reaction Condition (e): Primary amines, Diethylether,
Formaldehyde (37-41%), Con. HCl / RT, stirring.
Department of Chemistry, Saurashtra University, Rajkot-360 005 37
R 1
N
HN
N
R 2
N
R 1
CH 3
CH 3