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Chapter – 1 Preparation and Yield optimization.....
Peaks obtained in the DEPT-135 were in the agreement of the carbons
present in the molecule.
1.6.4 ELEMENTAL ANALYSIS
Elemental analysis of the synthesized compounds was carried out on
Vario EL Carlo Erba 1108 which showed calculated and found percentage
values of Carbon, Hydrogen and Nitrogen in support of the structure of
synthesized compounds. The spectral and elemental analysis data are given
for individual compounds.
1.7 ANALYTICAL DATA
2-METHYL-1-(PIPERIDIN-1-YLMETHYL) INDOLINE (DNJ-101): IR (KBr, cm -
1
): 3070 (Ar-H), 2960 (–CH3), 2860 (–CH2), 1605, 1500, 1483, 1460 (Ar-H),
1368 (C-N, Ar, 3°); MS m/z = 230 (M + ); Anal. Calcd. for C15H22N2: C, 78.21; H,
9.63; N, 12.16. Found: C, 78.19; H, 9.64; N, 12.17.
2-METHYL-1-(MORPHOLIN-4-YLMETHYL) INDOLINE (DNJ-102): IR (KBr,
cm -1 ): 3068 (Ar-H), 2957 (–CH3), 2852 (–CH2), 1606, 1486, 1455 (Ar-H), 1365
(C-N, Ar, 3°), 1067 (C-O-C ); 1 H NMR (400 MHz, CDCl3): δ (ppm) 1.28 (3H,
m), 2.45 (4H, t), 2.62 (1H, s), 2.83 (1H, s), 3.14 (1H, qt), 3.73 (4H, t), 4.44
(2H, s), 6.63 (2H, m), 7.00 (2H, m); 13 C NMR (400 MHz, CDCl3): δ (ppm)
170.84, 152.47, 127.47, 124.22, 118.06, 107.13, 71.45, 67.05, 59.46, 51.48,
37.55, 14.35; MS m/z = 232 (M + ); Anal. Calcd. for C14H20N2O: C, 72.38; H,
8.68; N, 12.06. Found: C, 72.36; H, 8.64; N, 12.09.
2-METHYL-1-(PIPERAZIN-1-YLMETHYL) INDOLINE (DNJ-103): IR (KBr,
cm -1 ): 3234 (-NH), 3020 (Ar-H), 2966 (–CH3), 2839 (–CH2), 1604, 1556, 1538,
1463 (Ar-H), 1371 (C-N, Ar, 3°), 1314 (C-N, Ar, 2°); 1 H NMR (400 MHz,
CDCl3): δ (ppm) 1.31 (3H, m), 1.89 (1H, s), 2.58 (8H, m), 2.87 (2H, d), 3.14
(1H, qt), 4.42 (2H, s), 6.59 (2H, m), 6.98 (2H, m); 13 C NMR (400 MHz, CDCl3):
δ (ppm) 157.37, 133.13, 132.08, 128.86, 122.26, 112.39, 75.54, 63.98, 56.09,
Department of Chemistry, Saurashtra University, Rajkot-360 005 53