Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FIG4F
91936
FIMRG
87995
synthesis of IgG. The two most commonly used diagnostic laboratory tests for multiple sclerosis are
CSF index and oligoclonal banding. The CSF index is the CSF IgG to CSF albumin ratio compared to
the serum IgG to serum albumin ratio. The CSF index is therefore an indicator of the relative amount of
CSF IgG compared to serum and any increase in the index is a reflection of IgG production in the
central nervous system. The IgG synthesis rate is a mathematical manipulation of the CSF index data
and can also be used as a marker for CNS inflammatory diseases.
Useful For: The cerebrospinal fluid (CSF) index is useful in the diagnosis of individuals with multiple
sclerosis. In the absence of a paired CSF and serum specimen, the CSF IgG/albumin ratio can be assessed.
The index is independent of the activity of the demyelinating process.
Interpretation: Cerebrospinal fluid IgG index is positive (elevated) in approximately 80% of patients
with multiple sclerosis.
Reference Values:
CSF IgG: 0.0-8.1 mg/dL
CSF albumin: 0.0-27.0 mg/dL
CSF IgG/albumin: 0.00-0.21
Clinical References: 1. Tourtellotte WW, Walsh MJ, Baumhefner RW, Staugaitis SM, Shapshak P:
The current status of multiple sclerosis intra-blood-brain-barrier IgG synthesis. Ann NY Acad Sci
436:52-67,1984 2. Bloomer LC, Bray PF: Relative value of three laboratory methods in the diagnosis of
multiple sclerosis. Clin Chem 27(12):2011-2013,1981 3. Hische EAH, vander Helm HJ: Rate of synthesis
of IgG within the blood-brain barrier and the IgG index compared in the diagnosis of multiple sclerosis.
Clin Chem 33(1):113-114,1987 4. Swanson JW: Multiple Sclerosis: Update in diagnosis and review of
prognastic factors. Mayo Clin Proc 64:577-585,1989 5. Markowitz H, Kokmen E: Neurologic diseases
and the cerebrospinal fluid immunoglobulin profile. Mayo Clin Proc 58:273-274,1983
IgG4 Food Panel VIII
Reference Values:
Corn IgG4 < 0.15 mcg/mL
Egg White IgG4 < 0.15 mcg/mL
Milk Cow IgG4 < 0.15 mcg/mL
Peanut IgG4 < 0.15 mcg/mL
Soybean IgG4 < 0.15 mcg/mL
Wheat IgG4 < 0.15 mcg/mL
The reference range listed on the report is the lower limit of quantitation for the assay. The clinical
utility of food-specific IgG4 tests has not been established. These tests can be used in special clinical
situations to select foods for evaluation by diet elimination and challenge in patients who have
food-related complaints. It should be recognized that the presence of food-specific IgG4 alone cannot be
taken as evidence of food allergy and only indicates immunologic sensitization by the food allergen in
question. This test should only be ordered by physicians who recognize the limitations of the test.
Test Performed by: Viracor-IBT Laboratories
1001 NW Technology Dr.
Lee's Summit, MO 64086
Imatinib Mesylate Responsive Genes, Locus Anomalies, FISH
Clinical Information: Myeloid neoplasms are primary disorders of the bone marrow cells. These
malignancies encompass several entities with extremely varied clinical courses, including acute myeloid
leukemias (AML), chronic myeloproliferative disorders (CMPD), and myelodysplastic syndromes. The
underlying genetic mechanisms associated with these malignancies are varied and only a portion of the
genetic anomalies have targeted therapies clinically available. One group of genes, including ABL1
(Abelson murine leukemia viral oncogene homolog 1), ABL2 (Abelson murine leukemia viral oncogene
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