Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

TLU
8603
TLB
8149
DNA probe studies. Since iron deficiency can mimic thalassemias, ferritin levels are measured to evaluate
this possibility.
Useful For: Diagnosis of thalassemia
Interpretation: A hematopathologist expert in these disorders evaluates the case, appropriate tests
are performed, and an interpretive report is issued.
Reference Values:
Definitive results and an interpretive report will be provided.
Clinical References: Hoyer JD, Hoffman DR: The thalassemia and hemoglobinopathy syndromes.
In Clinical Laboratory Medicine. 2nd edition. Edited by KD McMlatchey. Philadelphia, Lippencott
Williams and Wilkins, 2002, pp 866-892
Thallium, 24 Hour, Urine
Clinical Information: Thallium is found in some depilatories and rodenticides. Accidental
ingestion may lead to vomiting, diarrhea, and leg pains followed by a severe and sometimes fatal
sensorimotor polyneuropathy and renal failure. Alopecia (hair loss) may occur 3 weeks after poisoning.
The fatal dose is approximately 1 g.
Useful For: Detecting toxic thallium exposure
Interpretation: Normal daily output is 10
mcg/day. The long-term consequences of such an exposure are poor.
Reference Values:
0-1 mcg/specimen
Reference values apply to all ages.
Clinical References: 1. Bank WJ, Pleasure DE, Suzuki K, et al: Thallium poisoning. Arch Neurol
1972;26:456-464 2. Pelclova D, Urban P, Ridson P, et al: Two-year follow-up of two patients after
severe thallium intoxication. Hum Exp Toxicol. 2009 May;28(5):263-272 3. Zhao G, Ding M, Zhang B,
et al: Clinical manifestations and management of acute thallium poisoning. Eur Neurol
2008;60(6):292-297
Thallium, Blood
Clinical Information: Thallium is a by-product of lead smelting. The clinical interest in thallium
derives primarily from its use as a rodenticide since this is the most frequent route of human exposure.
Thallium is rapidly absorbed via ingestion, inhalation, skin contact, and through the mucous membranes
of the mouth, gastrointestinal tract, and lungs. It is considered to be as toxic as lead and mercury, with
similar sites of action. The mechanism of action of thallium is: -Competition with potassium at cell
receptors to affect ion pumps -Inhibition of DNA synthesis -Binds to sulfhydryl groups on proteins in
neural axons -Concentrates in renal tubular cells and reacts with protein to cause necrosis Patients
exposed to high doses of thallium (>1 g) present with alopecia (hair loss), peripheral neuropathy and
seizures, and renal failure.
Useful For: Detecting toxic thallium exposure
Interpretation: Normal blood concentrations are 10 ng/mL, and blood concentrations as high as 50 ng/mL. The long-term sequelae
from such an exposure is poor.
Reference Values:
0-1 ng/mL
Reference values apply to all ages.
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