Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

TAMV
82514
TDP
85753
the therapeutic antibody
Interpretation: The immunophenotyping report will summarize the pattern of antigenic expression on
malignant cells and, if necessary, the normal cellular counterpart(s) that correspond to the therapeutic
monoclonal antibody target.
Reference Values:
Normal individuals have B-lymphocytes, T-lymphocytes, or myeloid cells that express the corresponding
cell-surface antigen(s) in question.
Clinical References: 1. Davis AT: Monoclonal antibody-based therapy of lymphoid neoplasms:
what's on the horizon? Semin Hematol 2000;37(4 Suppl 7):34-42 2. Czuczman MS, Grillo-Lopez AJ,
White CA, et al: Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric
anti-CD20 monoclonal antibody and CHOP chemotherapy. J Clin Oncol 1999;17:268-276 3. Flynn JM,
Byrd JC: Campath-1H monoclonal antibody therapy. Curr Opin Oncol 2000;12:574-581 4. Kreitman RJ,
Wilson WH, Bergeron K, et al: Efficacy of the anti-CD22 recombinant immunotoxin BL22 in
chemotherapy-resistant hairy-cell leukemia. N Eng J Med 2001;345:241-247 5. van der Velden VH, te
Marvelde JG, Hoogeveen PG, et al: Targeting of the CD33-calicheamicin immunoconjugate Mylotarg
(CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and
normal myeloid cells. Blood 2001;97:3197-3204
Thermoactinomyces vulgaris, IgG Antibodies, Serum
Clinical Information: Thermoactinomyces vulgaris is a causative agent of hypersensitivity
pneumonitis (HP). Other causative microorganisms include Micropolyspora faeni and Aspergillus
fumigatus. While the immunopathogenesis of HP is not known, several immune mechanisms are
postulated to play a role, including both cellular and humoral mechanisms.(1)
Useful For: Evaluating patients suspected of having hypersensitivity pneumonitis induced by exposure
to this antigen
Interpretation: Elevated concentrations of IgG antibodies to Thermoactinomyces vulgaris are
consistent with the diagnosis of hypersensitivity pneumonitis (HP) caused by exposure to this antigen.
Elevated concentrations of IgG antibodies to Thermoactinomyces vulgaris were found in a small number
of sera from patients with HP (4%).(2)
Reference Values:
0-12 years: < or =6.6 mg/L
13-18 years: < or =11.0 mg/L
>18 years: < or =23.9 mg/L
Clinical References: 1. Fink JN, Zacharisen MC: Hypersensitivity pneumonitis. In Allergy
Principles and Practice. Vol. 1. 5th edition. Edited by E Middleton Jr, CE Reed, EF Ellis, et al. St. Louis,
MO, Mosby Year Book Inc., 1998, Chapter 19 2. Anderson E, Jacob GL, Roberts GD, Homburger HA:
Comparative evaluation of enzyme immunoassay and immunodiffusion for detection of IgG antibodies to
hypersensitivity pneumonitis antigens. Poster Presentation AAAAI Annual Meeting, San Diego, CA,
March 3-8, 2000. J Allergy Clin Immunol 2000;105:S304
Thiamin (Vitamin B1), Whole Blood
Clinical Information: Thiamin (vitamin B1) is an essential vitamin required for carbohydrate
metabolism, brain function, and peripheral nerve myelination. Thiamin is obtained from the diet. Body
stores are limited and deficiencies can develop quickly. The total thiamin pool in the average adult is
about 30 mg. An intake of 0.5 mg per 1,000 kcal per day is needed to maintain this pool. Due to its
relatively short storage time, marginal deficiency can occur within 10 days and more severe deficiency
within 21 days if intake is restricted. Approximately 80% of all chronic alcoholics are thiamin deficient
due to poor nutrition. However, deficiency also can occur in individuals who are elderly, have chronic
gastrointestinal problems, have marked anorexia, are on cancer treatment, or are receiving diuretic
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