Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FBUS
91115
BUAUC
83188
Buspirone (Buspar)
5785 Corporate Avenue
Cypress, CA 90630-4750
Reference Values:
Therapeutic and toxic ranges have not been established.
Expected serum buspirone concentrations in patients taking
recommended daily dosages: up to 10.00 ng/mL.
Test performed by: Medtox Laboratories, Inc.
402 W. County Road D
St. Paul, MN 55112
Busulfan, Intravenous Dose, Area Under the Curve (AUC),
Plasma
Clinical Information: Busulfan is an alkylating agent used to ablate bone marrow cells before
hematopoietic stem cell transplant.(1) Busulfan is typically administered in intravenous (IV) doses of 0.8
mg/kg once every 6 hours over 4 days, a total of 16 doses. Dose-limiting toxicity of busulfan is hepatic
veno-occlusive disease. To avoid toxicity while ensuring busulfan dose adequacy to completely ablate the
bone marrow, IV dosing should be guided by pharmacokinetic (PK) evaluation of area under the curve
(AUC) and clearance after the first dose.(2) The PK evaluation should be carried out at the end of the first
dose, with results of PK testing available to facilitate dose adjustment before beginning the fifth dose.
Useful For: Guiding dosage adjustments to achieve complete bone marrow ablation while minimizing
dose-dependent toxicity
Interpretation: This test should only be ordered when the following criteria are met: -Busulfan dosing
protocol must be intravenous (IV) administration of 8 mg/kg doses every 6 hours over 4 days, for a total
of 16 doses -Specimens must be drawn as described below: - 1 specimen drawn immediately after
termination of a 2-hour IV infusion of busulfan - 1 specimen drawn 1 hour after the infusion is terminated
- 1 specimen drawn 2 hours after the infusion is terminated - 1 specimen drawn 4 hours after the infusion
is terminated These results will be used to calculate a 6-hour area under the curve (AUC). If a different
dosing or specimen collection protocol is used, or if different calculations are required, please contact the
Laboratory Director. The optimal result for AUC (6 hour) derived from this pharmacokinetic (PK)
evaluation of IV busulfan is 1,100 mcmol*min. AUC results >1,500 mcmol*min are associated with
hepatic veno-occlusive disease. A dose reduction should be considered before the next busulfan infusion.
AUC results