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FAMS
91540
drug allergy, others develop resistant isolates due to noncompliance, and some antimicrobials penetrate
the central nervous system better than others. Therefore, the selection of appropriate agents becomes
extremely important to patient outcome.
Useful For: Determining the resistance of species of Nocardia and other aerobic actinomycetes to
antimicrobial agents
Interpretation: Interpretive values for susceptibility testing of Nocardia species using a broth
microdilution method. (Values expressed in mcg/mL): Antimicrobial Agent Interpretations S I R
Trimethoprim/ Sulfamethoxazole(3) < or = 2/38 - > or =4/76 Linezolid(2) < or =8 - - Ciprofloxacin < or
=1 2 > or =4 Imipenem < or =4 8 > or =16 Moxifloxacin(1,3) - - - Cefepime(3) < or =8 16 > or =32
Augmentin(3) < or =8/4 16/8 > or =32/16 Amikacin < or =8 - > or =16 Ceftriaxone(3) < or =8 16-32 >
or =64 Doxycycline < or =1 2-4 > or =8 Minocycline(3) < or =1 2-4 > or =8 Tobramycin < or =4 8 > or
=16 Clarithromycin < or =2 4 > or =8
Reference Values:
Antimicrobial Agent Concentration Range mcg/mL Interpretations
S I R
Trimethoprim/ Sulfamethoxazole(3) 0.25/4.75-8/152 < or =2/38 - > or =4/76
Linezolid(2) 1-32 < or =8 - -
Ciprofloxacin 0.12-4 < or =1 2 > or =4
Imipenem 2-64 < or =4 8 > or =16
Moxifloxacin(1,3) 0.25-8 - - -
Cefepime(3) 1-32 < or =8 16 > or =32
Augmentin(3) 2/1-64/32 < or =8/4 16/8 > or =32/16
Amikacin 1-64 < or =8 - > or =16
Ceftriaxone(3) 4-64 < or =8 16-32 > or =64
Doxycycline 0.12-16 < or =1 2-4 > or =8
Minocycline(3) 1-8 < or =1 2-4 > or =8
Tobramycin 1-16 < or =4 8 > or =16
Clarithromycin 0.06-16 < or =2 4 > or =8
Clinical References: 1. Corti ME, Villafane-Fioti MF: Nocardiosis: a review. Int J Infect Dis
2003;7:243-250 2. Saubolle MA, Sussland D: Nocardiosis: review of clinical and laboratory experience.
J Clin Microbiol 2003;41:4497-4501 3. Brown-Elliott BA, Brown JM, Conville PS, Wallace RJ Jr:
Clinical and laboratory features of the Nocardia species based on current molecular taxonomy. Clin
Microbiol Rev 2006;19:259-282
Antimicrobial Susceptibility, Serum Bactericidal Test
Schlichter
Reference Values:
Interpretation:
Results are reported as a titered value. That is, the dilution of serum or body fluid showing either a
bacteristatic and/or bactericidal effect. Bactericidal levels of 1:8 or greater are considered adequate
antibiotic dosage in most cases.
Test Performed By: Focus Diagnostics, Inc.
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