Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FHSAB
57434
FHERV
57305
cerebrospinal fluid (CSF) specimens in culture systems, and the serologic diagnosis of HSV CNS
disease has not been informative during early onset disease. HSV PCR detection from CSF is a sensitive
and specific alternative for detection of disease involving the CNS, as well as oral, genital, ocular, and
other sites.
Useful For: Aiding in the rapid diagnosis of herpes simplex virus (HSV) infections, including
qualitative detection of HSV DNA in cerebrospinal fluid and other (non-blood) clinical specimens
Qualitative detection of HSV DNA
Interpretation: This is a qualitative assay; results are reported either as negative or positive for herpes
simplex virus (HSV) type 1 or HSV type 2, or HSV indeterminate. Detection of HSV DNA in clinical
specimens supports the clinical diagnosis of infection due to the virus. The lower limit of detection of
LightCycler PCR is 10 copies DNA target per microliter. HSV DNA is not detected in cerebrospinal fluid
from patients without central nervous system disease caused by this virus.
Reference Values:
Not applicable
Clinical References: 1. Schiffer JT, Corye L: New concepts in understanding genital herpes. Curr
Infect Dis Rep Nov 2009;11(6):457-464 2. Espy MJ, Uhl JR, Svien KA: Laboratory diagnosis of herpes
simplex virus infections in the clinical laboratory by LightCycler PCR. J Clin Microbiol
2000;38(2):795-799 3. Espy MJ, Ross TK, Teo R: Evaluation of LightCycler PCR for implementation of
laboratory diagnosis of herpes simplex virus infections. J Clin Microbiol 2000;38(8):3116-3118 4.
Sauerbrei A, Eichhorn U, Hottenrott G, Wutzler P: Virological diagnosis of herpes simplex encephalitis. J
Clin Virol 2000;17(1):31-36 5. Mitchell PS, Espy MJ, Smith TF, et al: Laboratory diagnosis of central
nervous system infections with herpes simplex virus by PCR performed with cerebrospinal fluid
specimens. J Clin Microbiol 1997;35(11):2873-2877 6. Yi-Wei T, Mitchell PS, Espy MJ, et al: Molecular
diagnosis of herpes simplex virus infections in the central nervous system. J Clin Microbiol
1999;37(7):2127-2136
Herpes Simplex Virus 1/2 Antibody (IgM), IFA with Reflex to
Titer, Serum
Reference Values:
Herpes Simplex Virus 1/2 Antibody (IgM), IFA with Reflex to Titer, Serum
Reference Range: Negative
The IFA procedure for measuring IgM antibodies to HSV 1 and HSV 2 detects both type-common and
type-specific HSV antibodies. Thus, IgM reactivity to both HSV 1 and HSV 2 may represent crossreactive
HSV antibodies rather than exposure to both HSV 1 and HSV 2.
HSV 1 IgM Titer
HSV 2 IgM Titer
Herpes Simplex Virus by PCR
Reference Values:
Not Detected
This test is pursuant to an agreement with Roche Molecular Systems, Inc.
Test Performed By: ARUP Laboratories
500 Chipeta Way
Salt Lake City, Utah 84108
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