Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

CENTA
110006
CEAC
82387
Centromere Antibodies, Serum
Clinical Information: Antinuclear antibodies are seen in a number of autoimmune disorders such as
systemic lupus erythematosus, mixed connective tissue disease, rheumatoid arthritis, Sjogrenâ€s
syndrome, and progressive systemic sclerosis. One autoantibody that produces a distinct staining pattern
is the anticentromere antibody (ACA). ACA occurs in patients with the calcinosis, Raynaud's
phenomenon, esophageal hypomotility, sclerodactyly, and telangiectasia (CREST) syndrome variant of
PSS.
Useful For: Evaluation of patients with clinical signs and symptoms compatible with systemic
sclerosis
Interpretation: A positive test for anticentromere antibody (ACA) is strongly associated with
calcinosis, Raynaud's phenomenon, esophageal hypomotility, sclerodactyly, and telangiectasia (CREST)
syndrome. In various reported clinical studies, ACA occur in 50% to 96% of patients with CREST
syndrome. The presence of detectable levels of ACA may antedate the appearance of diagnostic clinical
features of CREST syndrome, in some cases by several years.
Reference Values:
Negative (titer of