Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

ZMMLS
8073
MMLSA
56031
Useful For: Determination of resistance of rapidly growing mycobacteria to antimicrobial agents
Interpretation: Results are reported as the minimum inhibitory concentration in micrograms/mL.
Reference Values:
Antimicrobial Susceptible (mcg/mL) Intermediate (mcg/mL) Resistant (mcg/mL)
Amikacin < or =16 32 > or =64
Cefoxitin < or =16 32-64 > or =128
Ciprofloxacin < or =1.0 2.0 > or =4.0
Clarithromycin < or =2.0 4.0 > or =8.0
Doxycycline < or =1.0 2.0-8.0 > or =16
Imipenem < or =4.0 8.0 > or =16
Tobramycin < or =4.0 8.0 > or =16
Linezolid < or =8 16 > or =32
Trimethoprim/Sulfamethoxazole < or =2/38 - > or =4/76
Moxifloxacin < or =1.0 2 > or =4.0
Tigecycline No interpretations available
Clinical References: 1. Brown-Elliott BA, Wallace RJ Jr.: Clinical and taxonomic status of
pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria. Clin Microbiol Rev 2002
October;15:716-746 2. Colombo RE, Olivier KN: Diagnosis and treatment of infections caused by rapidly
growing mycobacteria. Semin Respir Crit Care Med 2008 October;29:577-588
Antimicrobial Susceptibility, Aerobic Bacteria, MIC
Clinical Information: Antimicrobial susceptibility testing (AST) determines the minimum inhibitory
concentration (MIC) (of a series of increasing concentrations) of antimicrobial incorporated in agar plates,
which inhibits the growth of bacteria inoculated on the surface of the agar. Prior studies have determined
for each antimicrobial a "breakpoint" or MIC value, above which the bacterium being tested would be
considered resistant to that agent. The most important factor contributing to the determination of the
"breakpoint" is probably the expected serum concentration of antimicrobial achieved after giving the
usual dosage. The "category" result ("susceptible" or "resistant") provided along with the MIC is
determined by comparing the MIC result with the "breakpoint." AST should be performed on pure culture
isolates of pathogenic (or potentially pathogenic in special situations) bacteria grown from specimens that
have been appropriately collected so as not to confuse clinically significant isolates with normal flora.
Useful For: Determining the in vitro susceptibility of aerobic bacteria involved in human infections
Interpretation: A "susceptible" category result and a low minimum inhibitory concentration value
indicate in vitro susceptibility of the organism to the antimicrobial tested.
Reference Values:
Results are reported as MIC in mcg/mL and as susceptible, intermediate, or resistant according to the
CLSI guidelines.
Clinical References: Cockerill FR: Conventional and genetic laboratory tests used to guide
antimicrobial therapy. Mayo Clin Proc 1998;73:1007-1021
Antimicrobial Susceptibility, Anaerobic Bacteria, MIC
Clinical Information: Anaerobic bacteria make up a large part of the human bodyâ€s normal flora
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