Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

TORC
80804
=2 in paired sera (acute and convalescent) IgG values (ie, seroconversion), along with a convalescent
antibody level of >6, is indicative of a recent infection. The infection may either be primary or a
reactivation of a preexisting latent process with active viral excretion. Seroconversion indicates infection
subsequent to the first negative specimen. CMV infections are quite common. Approximately 60% to
85% of the population is believed to be infected by age 18. Herpes Simplex Virus (HSV): The presence of
antibodies specific for HSV type 1 or 2 indicates infection with the corresponding serotype of the virus. A
single positive specimen only indicates exposure at some point in time (past or recent). Seroconversion,
determined by parallel testing of acute and convalescent phase specimens, is required to determine
whether the infection is a current active infection or a past exposure. Seroconversion indicates infection
subsequent to the first negative specimen.
Reference Values:
Toxoplasma ANTIBODY, IgG
or =8 IU/mL (positive)
RUBELLA ANTIBODIES, IgG
Negative
CYTOMEGALOVIRUS (CMV) ANTIBODIES, IgG
or =6 AU/mL (positive)
A convalescent IgG antibody level of >6 AU/mL combined with a ratio of > or =2 in a paired sera
(seroconversion) IgG titer indicates recent infection. The presence of only IgG antibodies generally
indicates past infection with CMV.
HERPES SIMPLEX VIRUS (HSV) TYPE 1, IgG
Negative (reported as positive, negative, or equivocal)
HERPES SIMPLEX VIRUS (HSV) TYPE 2, IgG
Negative (reported as positive, negative, or equivocal)
Clinical References: 1. Luft BJ, Remington JS: Toxoplasmic encephalitis in AIDS. Clin Infect Dis
1992 August;15(2):211-222 2. Wong SY, Remington JS: Toxoplasmosis in pregnancy. Clin Infect Dis
1994 June;18(6):853-862 3. Yelland MJ: Rubella immune status in general practice. Aust Fam
Physician 1989 Oct;18(10):1279-1281, 1284-1285 4. Recommendation of the Immunization Practices
Advisory Committee: Centers for Disease Control Morbidity and Mortality Weekly Report
1981;30:37-47 5. Kusne S, Shapiro R, Fung J: Prevention and treatment of cytomegalovirus infection in
organ transplant recipients. Transpl Infect Dis 1999 Sep;1(3):187-203 6. Rubin RH: Importance of
CMV in the transplant population. Transpl Infect Dis 1999;1(1):3-7 7. Ashley RL, Wald A: Genital
herpes: review of the epidemic and potential use of type-specific serology. Clin Microbiol Rev 1999
Jan;12(1):1-8 8. Ashley RL, Wu L, Pickering JW, et al: Premarket evaluation of a commercial
glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific antibodies. J Clin
Microbiol 1998 Jan;36(1):294-295 9. Brown ZA, Selke S, Zeh J, et al: The acquisition of herpes
simplex virus during pregnancy. N Engl J Med 1997 Aug 21;337(8):509-515 10. Lafferty WE, Coombs
RW, Benedetti J, et al: Recurrences after oral and genital herpes simplex virus infection. Influence of
site of infection and viral type. N Engl J Med 1987 June 4;316(23):1444-1449 11. Binnicker MJ,
Jespersen DJ, Harring JA: Evaluation of three multiplex flow immunoassays to enzyme immunoassay
for the detection and differentiation of IgG-class antibodies to Herpes Simplex Virus types 1 and 2. Clin
Vac Immunol 2010 Feb;17(2):253-257
TORCH Profile IgM
Clinical Information: Toxoplasma: Toxoplasma gondii is an obligate intracellular parasite that is
capable of infecting a variety of intermediate hosts, including humans. Infected definitive hosts (cats)
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