Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

GCC
81981
GALTM
88877
emergency department presentation, treatment, and disposition: current approaches and future aims: a
scientific statement from the American Heart Association. Circulation 2010;122:1975-1996 2. Felker GM,
Fiuzat M, Shaw LK, et al: Galectin-3 in Ambulatory Patients With Heart Failure: Results from the
HF-ACTION Study. Circulation 2012 (in press) 3. Lok DJ, Van Der Meer P, de la Porte PW, et al:
Prognostic value of galectin-3, a novel marker of fibrosis, in patients with chronic heart failure: data from
the DEAL-HF study. Clin Res Cardiol 2010 May;99(5):323-328 4. de Boer RA, Lok DJ, Jaarsma T, et al:
Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction.
Ann Med 2011 Feb;43(1):60-68 5. Christenson RH, Duh SH, Wu AH, et al: Multi-center determination of
galectin-3 assay performance characteristics: Anatomy of a novel assay for use in heart failure. Clin
Biochem 2010 May;43(7-8):683-690
Gallstone Cholesterol Content
Clinical Information: Most gallstones are soft, flesh colored, and consist of a high percentage of
cholesterol. Formation of gallstones is the result of the gallbladder breaking down the molecular
complex between bile salts and cholesterol. At this point, the cholesterol deposits about some
microscopic nidus to form gallstones.
Useful For: This assay provides information on the cholesterol content of the gall stones. This test
can aid the physician in designing a strategy for management of the patient's problem when
cholecystectomy would be problematic.
Interpretation: The presence of a high percentage of cholesterol in the gallstone suggests the
process by which the gallstone is formed.
Reference Values:
Not applicable
GALT Gene, Full Gene Analysis
Clinical Information: Classic galactosemia is an autosomal recessive disorder of galactose
metabolism caused by mutations in the galactose-1-phosphate uridyltransferase (GALT) gene. The
complete or near complete deficiency of the GALT enzyme is life threatening. If left untreated,
complications include liver failure, sepsis, mental retardation, and death. Galactosemia is treated by a
galactose-free diet, which allows for rapid recovery from the acute symptoms and a generally good
prognosis. Despite adequate treatment from an early age, children with galactosemia remain at
increased risk for developmental delays, speech problems, and abnormalities of motor function.
Females with galactosemia are at increased risk for premature ovarian failure. The prevalence of classic
galactosemia is approximately 1 in 30,000. Duarte variant galactosemia (compound heterozygosity for
the Duarte variant, N314D, and a classic mutation) is generally associated with higher levels of GALT
activity (5%-20%) than classic galactosemia (