Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

CDIP
89860
COTT
82859
0-2 years: not established
3-8 years: 1.4-20 mcg/24 hours
9-12 years: 2.6-37 mcg/24 hours
13-17 years: 4.0-56 mcg/24 hours
> or =18 years: 3.5-45 mcg/24 hours
CORTISONE
0-2 years: not established
3-8 years: 5.5-41 mcg/24 hours
9-12 years: 9.9-73 mcg/24 hours
13-17 years: 15-108 mcg/24 hours
> or =18 years: 17-129 mcg/24 hours
Use the factors below to convert each analyte from mcg/24 hours to nmol/24 hours:
Conversion factors
Cortisol: mcg/24 hours x 2.76=nmol/24 hours (molecular weight=362.5)
Cortisone: mcg/24 hours x 2.78=nmol/24 hours (molecular weight=360)
Clinical References: 1. Findling JW, Raff H: Diagnosis and differential diagnosis of Cushing's
syndrome. Endocrinol Metab Clin North Am 2001;30:729-747 2. Boscaro M, Barzon L, Fallo F, Sonino
N: Cushing's syndrome. Lancet 2001;357:783-791 3. Taylor RL, Machacek D, Singh RJ: Validation of a
high-throughput liquid chromatography-tandem mass spectrometry method for urinary cortisol and
cortisone. Clin Chem 2002;48:1511-1519
Corynebacterium diphtheriae Culture
Clinical Information: Diphtheria occurs in 2 forms, respiratory and cutaneous, but is an uncommon
disease in the United States since the advent of universal vaccination in the 1940â€s. The organism is
carried in the upper respiratory tract and is spread by droplet infection or hand-to mouth contact. The
incubation period averages 2 to 5 days. The illness is characterized by fever, malaise, and a sore throat. A
swab from beneath the thick pseudomembrane covering the posterior pharynx is the preferred specimen
for culture. The organisms multiplying at the infection site produce an exotoxin that may also result in
systemic complications affecting the heart, nervous system, etc. Diphtheria is treated by prompt
administration of antitoxin, as well as antibiotics (penicillin or a macrolide) to eliminated the focus of
infection and prevent the spread of the organism. The diagnosis of diphtheria is based on clinical criteria
and treatment must be initiated prior to laboratory confirmation. Testing is indicated to confirm a clinical
diagnosis.
Useful For: Confirmation of the clinical diagnosis of diphtheria
Interpretation: A positive result supports a diagnosis of diphtheria A negative result is evidence
against a diagnosis of diphtheria but does not definitively rule out this disease (eg, culture may be
negative because of prior antimicrobial therapy)
Reference Values:
No growth of Corynebacterium diphtheriae
Clinical References: Mandell GL, Bennett JE, Dolin R: In Principles and Practice of Infectious
Diseases. 6th edition. Philadelphia, PA, Elsevier Inc., 2005, pp 2457-2465
Cotton Fiber, IgE
Clinical Information: Clinical manifestations of immediate hypersensitivity (allergic) diseases are
caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from
immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE
antibodies interact with allergen. In vitro serum testing for IgE antibodies provides an indication of the
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