Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

SHELP
84407
Helicobacter pylori infection. Because serology may lack specificity, additional noninvasive tests can be
used to confirm Helicobacter pylori infection including the urease breath test (#81590 Helicobacter pylori
Breath Test) or stool antigen test for Helicobacter pylori (#81806 Helicobacter Pylori Antigen, Feces).
The gold standard for diagnosis of Helicobacter pylori disease is a biopsy of infected tissue and evaluating
the tissue by Gram, silver, Giemsa, or acridine orange stains; or by immunofluorescence or
immunoperoxidase methods; rapid urease testing; and/or culture.
Useful For: Screening for Helicobacter pylori infection
Interpretation: Patients with Helicobacter pylori infection nearly always develop antibodies of the
IgG class and less frequently develop antibodies of the IgA class. IgM antibodies may be produced
shortly after the onset of infection. Levels of IgM antibodies should decrease after successful treatment,
but may again increase if recurrence or relapse of infection occurs.
Reference Values:
Negative (Results with index value of or =18.00 but < or =20.00 are equivocal.)
Positive (Results with index values of >20.00 are positive.)
Clinical References: 1. Blaser MJ: Helicobacter pylori and related organisms. In Principles and
Practice of Infectious Diseases. Vol. 2. 4th edition. Edited by GL Mandell, R Dolin, JE Bennett.
Churchill Livingstone Inc., 1995, pp 156-164 2. Perez-Perez GI, Taylor DN, Bodhidatta L, et al:
Seroprevalence of Helicobacter pylori infections in Thailand. J Infect Dis 1990;29:2139-2143 3.
Drumm B, Perez-Perez GI, Blaser MJ, et al: Intrafamilial clustering of Helicobacter pylori infection. N
Engl J Med 1990;322:359-363 4. Morris AJ, Ali MR, Nicholson GI, et al: Long term follow-up of
voluntary ingestion of Helicobacter pylori. Ann Intern Med 1991;114:662-663 5. Evans DJ Jr, Evans
DG, Graham DY, et al: A sensitive and specific serologic test for detection of Campylobacter pylori
infection. Gastroenterology 1989;96:1004-1008 6. Glassman MS, Dallal S, Berezin SH, et al:
Helicobacter pylori related gastroduodenal disease in children. Diagnostic utility of enzyme-linked
immunosorbent assay (ELISA). Dig Dis Sci 1990;35:993-997
Helicobacter pylori Antibody, IgG, IgM, and IgA, Serum
Clinical Information: Helicobacter pylori is a spiral-shaped, gram-negative bacillus that has been
associated with gastritis, gastric and duodenal ulcers, and gastric malignancies. Helicobacter pylori is
found worldwide. In Caucasian populations in the United States and other industrialized countries,
Helicobacter pylori infection is infrequent in childhood. Prevalence increases 0.5% to 2% with each
year of age, reaching about 50% in those who are 60 or older. Prevalence rates appear to be higher in
blacks and Hispanics than in whites. In a random population of 200 apparently healthy blood donors
tested for Helicobacter pylori IgG antibody, the positive rate was 27.5% with an equivocal rate of 5.5%.
The diagnosis of Helicobacter pylori gastrointestinal disease is supported by the presence of serum
antibodies: IgG, IgM, or IgA, to the organism. Screening patients for the presence of antibodies to
Helicobacter pylori is a convenient, noninvasive means for assessing whether gastrointestinal symptoms
may be related to Helicobacter pylori infection. Because serology may lack specificity, additional
noninvasive tests can be used to confirm Helicobacter pylori infection including the urease breath test
(UBT/81590 Helicobacter pylori Breath Test) or stool antigen test for Helicobacter pylori (HPSA/81806
Helicobacter Pylori Antigen, Feces). The gold standard for diagnosis of Helicobacter pylori disease is a
biopsy of infected tissue and evaluating the tissue by Gram, silver, Giemsa, or acridine orange stains; or
by immunofluorescence or immunoperoxidase methods; rapid urease testing; and/or culture.
Useful For: Screening for Helicobacter pylori infection
Interpretation: Patients with Helicobacter pylori infection nearly always develop antibodies of the
IgG class and less frequently develop antibodies of the IgA class. IgM antibodies may be produced
shortly after the onset of infection. Levels of IgM antibodies should decrease after successful treatment,
but may again increase if recurrence or relapse of infection occurs.
Reference Values:
IgG
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 867