Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FCBG
90148
FCORT
91644
CRANU
82920
21-deoxycortisol might be useful in these cases. This minor pathway metabolite accumulates in CYP21A2
deficiency, as it requires 21-hydroxylation to be converted to cortisol, but is usually not elevated in
CYP11B1 deficiency, since its synthesis requires 11-hydroxylation of 17-hydroxyprogesterone.
Reference Values:
< or =18 years: 18-1,970 ng/dL
>18 years: 53-1,560 ng/dL
Clinical References: 1. Von Schnakenburg K, Bidlingmaier F, Knorr D: 17-hydroxyprogesterone,
androstenedione, and testosterone in normal children and in prepubertal patients with congenital adrenal
hyperplasia. Eur J Pediatr 1980;133(3):259-267 2. Therrell BL: Newborn screening for congenital
adrenal hyperplasia. Endocrinol Metab Clin North Am 2001;30(1):15-30 3. Collett-Solberg PF:
Congenital adrenal hyperplasia: From genetics and biochemistry to clinical practice, part I. Clin Pediatr
2001;40:1-16 4. Forest MG: Recent advances in the diagnosis and management of congenital adrenal
hyperplasia due to 21-hydroxylase deficiency. Hum Reprod Update 2004;10:469-485 5.
Tonetto-Fernandes V, Lemos-Marini SH, Kuperman H, et al: Serum
21-deoxycortisol,17-hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal
hyperplasia: clinical and hormonal correlations and identification of patients with 11 beta-hydroxylase
deficiency among a large group with alleged 21-hydroxylase deficiency. J Clin Endocrinol Metab
2006;91:2179-2184
Cortisol Binding Globulin (Transcortin)
Reference Values:
Adult: 19-45 mg/L
Pediatric
Preterm Infants:
< 8 days: 6-26 mg/L
Pediatric data from pediatric research, 1994, 37:112-116
TEST PERFORMED BY QUEST DIAGNOSTICS, NICHOLS INSTITUTE
33608 ORTEGA HWY
SAN JUAN CAPISTRANO, CA 92690-6130
Cortisol, Free
Reference Values:
Adult Reference Ranges for Cortisol, Free, LC/MS/MS:
8:00-10:00 AM 0.07-0.93 mcg/dL
4:00-6:00 PM 0.04-0.45 mcg/dL
10:00-11:00 PM 0.04-0.35 mcg/dL
Test Performed by: Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130
Cortisol, Free, Random, Urine
Clinical Information: Cortisol is a steroid hormone synthesized from cholesterol by a multienzyme
cascade in the adrenal glands. It is the main glucocorticoid in humans and acts as a gene transcription
factor influencing a multitude of cellular responses in virtually all tissues. Cortisol plays a critical role
in glucose metabolism, maintenance of vascular tone, immune response regulation, and in the body's
response to stress. Its production is under hypothalamic-pituitary feedback control. Only a small
percentage of circulating cortisol is biologically active (free), with the majority of cortisol inactive
(protein bound). As plasma cortisol values increase, free cortisol (ie, unconjugated cortisol or
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