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Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

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AMA<br />

8176<br />

FMTDN<br />

91924<br />

FETCE<br />

91844<br />

hereditary colorectal neoplasms. Am J Surg Pathol 2005;29:96-104<br />

Mitochondrial Antibodies (M2), Serum<br />

Clinical Information: Antimitochondrial antibodies (AMAs) are detectable by indirect<br />

immunofluorescence in >90% of patients with primary biliary cirrhosis (PBC), but this method also<br />

detects AMAs of differing specificities in other diseases. The mitochondrial antigens recognized by<br />

AMAs in patients' sera have been classified numerically as M1 through M9, with the M2 antigen<br />

complex recognized by AMAs in sera from patients with PBC. M2 antigen is comprised of enzyme<br />

proteins of the 2-oxoacid dehydrogenase complex that are located on inner mitochondrial membranes.<br />

Included in this group of autoantigens are the pyruvate dehydrogenase complex, and 2-oxoglutarate<br />

dehydrogenase complex.<br />

Useful For: Establishing the diagnosis of primary biliary cirrhosis<br />

Interpretation: Positive results for antimitochondrial antibody (AMA) of M2 specificity are highly<br />

specific for primary biliary cirrhosis (PBC), and false-negative results are rare. A positive result for<br />

AMA of M2 specificity in a patient with clinical features of PBC is virtually diagnostic for this disease.<br />

Reference Values:<br />

Negative: or =1.0 Units<br />

Reference values apply to all ages.<br />

Clinical References: 1. Rich RR, et al: Infammatory hepatobiliary cirrhosis. In Clinical<br />

Immunology Principles and Practice. 3rd edition. Philadelphia, Elsevier, 2008 2. Muratori L, Granito A,<br />

Muratori P, et al: Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis:<br />

diagnostic and prognostic value. Clin Liver Dis 2008;12:261-276 3. Kaplan MM, Gershwin ME:<br />

Primary biliary cirrhosis. N Engl J Med 2005;353(12):1261-1273 4. Van Norstrand MD, Malinchoc M,<br />

Lindor KD, et al: Quantitative measurement of autoantibodies to recombinant mitochondrial antigens in<br />

patients with primary biliary cirrhosis: relationship to levels of autoantibodies to disease progression.<br />

Hepatology 1997;25(1):6-11<br />

Mitochondrial DNA Screening Panel (Point Mutations and<br />

Deletions)<br />

Reference Values:<br />

A final report will be faxed under separate cover.<br />

<strong>Test</strong> Performed by: Baylor <strong>Medical</strong> Genetics Laboratories<br />

2450 Holcombe Blvd.<br />

Houston, TX 77021<br />

Mitochondrial Respiratory Chain Enzyme Analysis - Skin<br />

Fibroblasts<br />

Reference Values:<br />

A final report will be faxed under separate cover.<br />

<strong>Test</strong> Performed by: Baylor <strong>Medical</strong> Genetics Laboratories<br />

2450 Holcombe Blvd.<br />

Houston, TX 77021<br />

Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong>Laboratories.com Page 1221

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