Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

PHIV
88635
mutations detected have been associated with 1 or both of the following outcomes: - Diminished virologic
response in some, but not all, patients having virus with these mutations - Intermediate decrease in
susceptibility of the virus to the specific drug -"Insufficient evidence" indicates that there is inadequate
direct or indirect evidence to determine susceptibility of the virus to the specific drug on the basis of the
genotypic mutations present, according to the opinion of the consensus panel of leading experts in the
field of HIV resistance. -"Unable to genotype" result indicates that the sequence data obtained are of poor
quality to determine the presence or absence of genotypic resistant mutations in the patient's HIV strain.
Possible causes of such poor sequence data include low HIV viral load (ie BCO value for the given drug.
-"Maximal response" indicates that the predicted FC in IC50 is < or =CCO1 value for the specific drug.
-"Reduced response" indicates that the predicted FC in IC50 is >CCO1 but < or =CCO2 values for the
specific drug. -"Minimal response" indicates that the predicted FC in IC50 is >CCO2 value for the
specific drug.
Reference Values:
Not applicable
Clinical References: 1. Hanna GJ: HIV-1 genotypic and phenotypic resistance. Clin Lab Med
2002;22:637-649 2. Cavert W, Balfour HH: Detection of antiretroviral resistance in HIV-1. Clin Lab
Med 2003;23:915-928 3. Cohen CJ, Hunt S, Sension M, et al: A randomized trial assessing the impact
of phenotypic resistance testing on antiretroviral therapy. AIDS 2002;16:579-588 4. Mazotta F, Caputo
SL, Torti C, et al: Real versus virtual phenotype to guide treatment in heavily pretreated patients:
48-week follow-up of the Genotipo-Fenotipo di Resistenza (GenPheRex) trial. J Acquir Immune Defic
Syndr 2003;32:268-280 5. Perez-Elias MJ, Garcia-Arata I, MuAoz V, et al: Phenotype or virtual
phenotype for choosing antiretroviral therapy after failure: a prospective, randomized study. Antivir
Ther 2003;8:577-584
HIV-1 Proviral DNA Qualitative Detection by PCR, Blood
Clinical Information: Human immunodeficiency virus (HIV)-1 infection in humans is usually
confirmed by detection of HIV-1-specific antibodies in serum. However, serologic testing may not
reliably identify HIV-1 infection in neonates with passively acquired maternal HIV-1 antibodies or with
incompletely developed immune systems, in individuals with early infection (