Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

HBC
8347
CORAB
32111
are negative Differentiation between acute and chronic/past hepatitis B infection in the presence of
positive anti-hepatitis B core
Interpretation: A positive result indicates recent acute hepatitis B infection. A negative result suggests
lack of recent exposure to the virus in preceding 6 months.
Reference Values:
Negative
See Viral Hepatitis Serologic Profiles in Special Instructions.
Clinical References: 1. Badur S, Akgun A: Diagnosis of hepatitis B infections and monitoring of
treatment. J Clin Virol 2001;21:229-237 2. Servoss JC, Friedman LS: Serologic and molecular diagnosis
of hepatitis B virus. Clin Liver Dis 2004;8:267-281
Hepatitis B Core Total Antibodies, Serum
Clinical Information: Hepatitis B core antibodies (anti-HBc Ab) appear shortly after the onset of
symptoms of hepatitis B infection and soon after the appearance of hepatitis B surface antigen (HBsAg).
Initially, anti-HBc Ab consist almost entirely of the IgM class, followed by appearance of anti-HBc IgG,
for which there is no commercial diagnostic assay. The anti-HBc total antibodies test, which detects both
IgM and IgG antibodies, and the test for anti-HBc IgM antibodies may be the only markers of a recent
hepatitis B infection detectable in the "window period." The window period begins with the clearance of
HBsAg and ends with the appearance of antibodies to hepatitis B surface antigen (anti-HBs Ab).
Anti-HBc total Ab may be the only serologic marker remaining years after exposure to hepatitis B.
Useful For: Diagnosis of recent or past hepatitis B infection Determination of occult hepatitis B
infection in otherwise healthy hepatitis B virus (HBV) carriers with negative test results for hepatitis B
surface antigen, anti-hepatitis B surface, anti-hepatitis B core IgM, hepatitis Be antigen, and anti-HBe.
This assay is not useful for differentiating among acute, chronic, and past/resolved hepatitis B infection.
This assay is FDA-approved for in vitro diagnostic use and not for screening cell, tissue, and blood
donors.
Interpretation: A positive result indicates acute, chronic, or past/resolved hepatitis B.
Reference Values:
Negative
Interpretation depends on clinical setting.
See Viral Hepatitis Serologic Profiles in Special Instructions.
Clinical References: 1. Badur S, Akgun A: Diagnosis of hepatitis B infections and monitoring of
treatment. J Clin Virol 2001;21(3):229-237 2. Servoss JC, Friedman LS: Serologic and molecular
diagnosis of hepatitis B virus. Clin Liver Dis 2004;8(2):67-281
Hepatitis B Core Total Antibodies, with Reflex to Hepatitis B
Core Antibody, IgM, Serum
Clinical Information: During the course of a typical case of acute hepatitis B viral (HBV) infection,
IgM antibodies to hepatitis B core antigen (anti-HBc IgM) are present in the serum shortly before clinical
symptoms appear. Anti-HBc total is detectable during the prodromal, acute, and early convalescent phases
when it exists as immunoglobulin M (IgM) anti-HBc. Anti-HBc IgM rises in level and is present during
the core window period, ie, after hepatitis B surface antigen disappears and before antibodies to hepatitis
B surface antigen appear. Anti-HBc total may be the only serologic marker remaining years after
exposure to HBV.
Useful For: Detection and differentiation between recent and past/resolved or chronic hepatitis B viral
(HBV) infection Diagnosis of recent HBV infection during the "window period" when both hepatitis B
surface antigen and antibodies to hepatitis B surface antigen are negative
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