Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FFLEX
90085
CYCL
81506
likelihood of rheumatoid arthritis (RA). A Mayo prospective clinical evaluation of the CCP antibody test
showed a diagnostic sensitivity for RA of 78% with fewer than 5% false positive results in healthy
controls (see Cautions). CCP antibodies have also been reported in approximately 40% of seronegative
RA patients, and, like rheumatoid factor (RF), a positive CCP antibody result indicates an increased
likelihood of erosive disease in patients with RA. High levels of CCP antibodies may be useful to identify
patients with aggressive disease, but further studies are needed to document this association. The level of
CCP antibodies may also correlate with disease activity in RA, but further studies are needed to document
this clinical application.
Reference Values:
or =60.0 U (strong positive)
Reference values apply to all ages.
Clinical References: 1. Banal F, Dougados M, Combescure C, Gossec L: Sensitivity and
specificity of the American College of Rheumatology 1987 criteria for the diagnosis of rheumatoid
arthritis according to disease duration: a systemic literature review and meta-analysis. Ann Rheum Dis
2009 July;68:1184-1191 2. Schellekens GA, Visser H, De Jong BA, et al: The diagnostic properties of
rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000
Jan;43(1):155-163 3. Visser H, le Cessie S, Vos, K, et al: How to diagnose rheumatoid arthritis early: a
prediction model for persistent (erosive) arthritis. Arthritis Rheum 2002 Feb;46(2):357-365
Cyclobenzaprine (Flexeril)
Reference Values:
Reference Range: 10-30 ng/mL
Test Performed By:
Medtox Laboratories, Inc.
402 W. County Road D
St. Paul, MN 55112
Cyclospora Stain
Clinical Information: In recent years, Cyclospora cayatenensis has been shown to cause (in
humans) gastroenteritis characterized by watery diarrhea and systemic symptoms such as anorexia,
malaise, weight loss, and general debilitation. The organism which was originally thought to be a
cyanobacteria or blue-green algae is now recognized as a protozoan parasite belonging to the coccidian
group. It is similar in morphology and staining to Cryptosporidium but is approximately twice as large.
Diarrhea caused by Cyclospora has been reported in Nepal, the Indian subcontinent, Southeast Asia, and
Latin America. It has been extensively studied in Peru and the species name derives from the university
where this work was done. Although most cases of cyclosporiasis have been seen in travelers to
developing countries, a focal outbreak due to contaminated water occurred at a Chicago medical center
in 1990. Also, in the summer of 1996, a widespread outbreak occurred in many areas of the United
States and Canada due to the importation of contaminated raspberries from Guatemala. Transmission is
probably fecal-oral and can be food borne or water-borne. The infection is usually self-limited but
symptoms can be prolonged. The infection usually responds to treatment with a sulfa-trimethoprim
combination.
Useful For: The identification of Cyclospora as a cause of infectious gastroenteritis See Parasitic
Investigation of Stool Specimens Algorithm in Special Instructions for other diagnostic tests that may
be of value in evaluating patients with diarrhea.
Interpretation: A report of Cyclospora species indicates the presence of this parasite in the patient's
feces.
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