Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

SPAG
8980
SGBF
8275
antibodies interact with allergen. In vitro serum testing for IgE antibodies provides an indication of the
immune response to allergen(s) that may be associated with allergic disease. The allergens chosen for
testing often depend upon the age of the patient, history of allergen exposure, season of the year, and
clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of
sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and
bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and
wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,
2007 Chapter 53, Part VI, pp 961-971
Special Red Cell Antigen Typing
Clinical Information: The presence or absence of a cellular antigen is an inherited trait. As a general
rule, individuals will not make antibody directed against an antigen present on their own red blood cells.
Useful For: Added proof of alloantibody specificity Determining possible antibody specificities in
complex cases This test is not done for the purpose of establishing paternity
Interpretation: Each antigen typed will be listed by name, followed by "pos" indicating that the
antigen is present, or by "neg" indicating that the antigen is absent.
Clinical References: Standards for Blood Banks and transfusion Services. 21st edition. AABB, 2002
Specific Gravity, Body Fluid
Clinical Information: Specific gravity (SG), the ration of the mass of a solution compared to the
mass of an equal volume of water, is an estimate of the concentration of substances dissolved in the
solution. Accessing whether a body fluid specimen is exudative or transudative in nature is the initial step
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1618