Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

PUPY
81420
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by RA McPherson, MR Pincus. New York, WB Saunders
Company, 2007, Chapter 53, Part VI, pp 961-971
Purine and Pyrimidine Panel, Urine
Clinical Information: Purines (adenine, guanine, xanthine, hypoxanthine) and pyrimidines (uracil,
thymine, cytosine, orotic acid) are involved in all biological processes, providing the basis for storage,
transcription, and translation of genetic information as RNA and DNA. Purines are required by all cells
for growth and survival and also play a role in signal transduction and translation. Purines and
pyrimidines originate primarily from endogenous synthesis, with dietary sources playing only a minor
role. The end product of purine metabolism is uric acid (2,6,8-trioxypurine), which must be excreted
continuously to avoid toxic accumulation. Due to the various roles these compounds play, the enzymes
catalyzing purine and pyrimidine metabolism function as "housekeeping" enzymes. Accordingly,
disorders of purine and pyrimidine metabolism can involve all organ systems at any age. Lesch-Nyhan
syndrome (complete deficiency of hypoxanthine-guanine phosphoribosyltransferase) was described in
1964 as the first disorder of purine metabolism. It is an X-linked disorder characterized by severe
neurologic impairment, the development of a compulsive self-destructive behavior, and uric acid
nephropathy. The diagnosis of the various disorders of purine and pyrimidine metabolism (more than 30
enzyme deficiencies have been described although only 17 are known to cause disease) is based on the
clinical presentation of the patient, determination of specific concentration patterns of purine and
pyrimidine metabolites, followed by confirmatory enzyme assays and/or molecular genetic testing.
Useful For: Evaluating patients with symptoms suspicious for disorders of purine and pyrimidine
metabolism Monitoring patients with disorders of purine and pyrimidine metabolism Laboratory
evaluation of primary and secondary hyperuricemias
Interpretation: A positive test result could be due to a genetic or nongenetic condition. Additional
confirmatory testing would be required. Abnormal concentrations of measurable compounds will be
reported along with an interpretation. The interpretation of an abnormal metabolite pattern includes an
overview of the results and of their significance, a correlation to available clinical information, possible
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1518