Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

SECOS
8243
FSEC
90173
FSED
91811
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by RA McPherson, MR Pincus. New York, WB Saunders
Company, 2007, Chapter 53, Part VI, pp 961-971
Secobarbital, Serum
Clinical Information: Secobarbital is a short-acting barbiturate with hypnotic properties used as a
preanesthetic agent and in the short-term treatment of insomnia.(1,2) Secobarbital is administered orally.
The duration of its hypnotic effect is about 3 to 4 hours. The drug distributes throughout the body, with a
volume of distribution (Vd) of 1.6 to 1.9 L/kg, and about 46% to 70% of a dose is bound to plasma
proteins. Metabolism takes place in the liver primarily via hepatic microsomal enzymes. Secobarbital's
half-life is about 15 to 40 hours (mean: 28 hours).(2,3)
Useful For: Monitoring secobarbital therapy
Interpretation: Therapeutic concentration: 1.0 to 2.0 mcg/mL Toxic concentration: >5.0 mcg/mL
Reference Values:
Therapeutic concentration: 1.0-2.0 mcg/mL
Toxic concentration: >5.0 mcg/mL
Concentration at which toxicity occurs varies and should be interpreted in light of clinical situation.
Clinical References: 1. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 10th
edition. New York, McGraw-Hill Book Company, 2001 2. Teitz Textbook of Clinical Chemistry and
Molecular Diagnostics. 4th edition. Edited by CA Burtis, ER Ashwood, DE Bruns. St. Louis, MO,
Elsevier Saunders, 2006, p 1091 3. Disposition of Toxic Drugs and Chemicals in Man. 7th edition. Edited
by RC Baselt. Foster City, CA, Biomedical Publications, 2004, p 1254
Secretin
Clinical Information: Secretin is a 27 amino acid basic peptide produced by S cells and released by
acid delivered into the duodenum. Secretin is released into the blood when duodenal pH drops below 4.
Secretin shares structural similarity with Glucagon, Gastric Inhibitory Polypeptide, Vasoactive Intestinal
Polypeptide, PHIM, and Growth Hormone- Releasing Hormone. Secretin is a potent stimulus for
bicarbonate secretion. Secretin also stimulates secretion of bile, release of Insulin, and release of Gastric
Pepsin in the stomach. Secretin inhibits Glucagon release, intestinal motility, and prevents the uptake of
water and sodium ions by the intestine. In normal patients, Secretin has little effect on Gastrin levels, but
stimulates Gastrin greatly in Zollinger-Ellison patients. Secretin is also elevated in Zollinger-Ellison
patients and in patients with duodenal ulcer. Secretin levels are low in patients with pernicious anemia and
achlorhydria. Secretin secretion can be suppressed by Somatostatin, Cimetidine, and
Methionine-Enkephalin.
Reference Values:
12-75 pg/mL (mean=25)
This test was developed and its performance characteristics determined by Inter Science Institute. It has
not been cleared or approved by the US Food and Drug Administration. The FDA has determined that
such clearance or approval is not necessary.
Test Performed by: Inter Science Institute
944 West Hyde Park
Inglewood, CA 90302
Sedative Hypnotic Panel, Urine-Forensic
Reference Values:
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