Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FPOC
81081
Reference Values:
Tanner Stages Age (Years) Reference Range (ng/dL)
Stage I (prepubertal)
Stage II 9.8-14.5 31-65
Stage III 10.7-15.4 50-100
Stage IV 11.8-16.2 48-140
Stage V 12.8-17.3 65-210 Females*
Tanner Stages Age (Years) Reference Range (ng/dL)
Stage I (prepubertal)
Stage II 9.2-13.7 42-100
Stage III 10.0-14.4 80-190
Stage IV 10.7-15.6 77-225
Stage V 11.8-18.6 80-240 *Source: Androstenedione. In
Pediatric Reference Ranges. Fourth
edition. Edited by SJ Soldin, C Brugnara,
EC Wong. Washington, DC, AACC Press,
2003, pp 32-34 ADULTS Males: 40-150
ng/dL Females: 30-200 ng/dL
Clinical References: 1. Von Schnakenburg K, Bidlingmaier F, Knorr D: 17-hydroxyprogesterone,
androstenedione, and testosterone in normal children and in prepubertal patients with congenital adrenal
hyperplasia. Eur J Pediatr 1980;133:259-267 2. Sciarra F, Tosti-Croce C, Toscano V:
Androgen-secreting adrenal tumors. Minerva Endocrinol 1995;20:63-68 3. Young WF Jr: Management
approaches to adrenal incidentalomas-a view from Rochester, Minnesota. Endocrinol Metab Clin North
Am 2000;21:671-696 4. Ibanez L, DiMartino-Nardi J, Potau N, Saenger P: Premature
adrenarche-normal variant or forerunner of adult disease? Endocrine Rev 2001;40:1-16 5.
Collett-Solberg P: Congenital adrenal hyperplasia: from genetics and biochemistry to clinical practice,
part I. Clin Pediatr 2001;40:1-16 6. Allolio B, Arlt W: DHEA treatment: myth or reality? Trends
Endocrinol Metab 2002;13:288-294
Aneuploidy Detection, Products of Conception (POC), FISH
Clinical Information: Products of conception (POC) are tissues created at conception that
spontaneously miscarry; these tissues include chorionic villi, fetal membranes, or fetal tissue.
Spontaneous miscarriages occur in 15% to 20% of all recognized human conceptions. While there are
many possible causes for miscarriages, chromosome anomalies can be identified in up to 50% of
first-trimester miscarriages. It is important to determine a possible chromosomal cause of the pregnancy
loss as this information impacts patient management and facilitates understanding of the reason for the
loss. Chromosomal aneuploidy, the gain or loss of chromosomes, is a major cause of early fetal demise.
Trisomy is the most common type of chromosome abnormality in spontaneous abortions and has been
observed for most chromosomes, with 13, 15, 16, 18, 21, 22, X, and Y being the most common.
Conventional chromosome analyses of POC (#8887 Chromosome Analysis, Autopsy, Products of
Conception, or Stillbirth) is a commonly performed method used to identify these common chromosome
aneuploidies. Conventional chromosome analysis involves fibroblast cultures. Unfortunately, 20% of
POC specimens fail to grow when cultured. A FISH method has been developed to analyze this subset
of cases or to be used when fresh tissue is not available for full chromosome analysis.
Useful For: Screening for the common chromosomal aneuploidies (13, 15, 16, 18, 21, 22, X, and Y)
in POC when fresh tissue is not available for full chromosome analysis Rapid detection of common
chromosomal aneuploidies or triploidy Determining the genetic cause of a miscarriage
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 141