Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

DESIP
81854
clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of
sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and
bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and
wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,
Chapter 53, Part VI, pp. 961-971, 2007
Desipramine, Serum
Clinical Information: Desipramine is a tricyclic antidepressant; it also is a metabolite of imipramine.
These drugs have also been employed in the treatment of enuresis (involuntary urination) in childhood
and severe obsessive-compulsive neurosis. Desipramine is the antidepressant of choice in patients where
maximal stimulation is indicated. The therapeutic concentration of desipramine is 100 to 300 ng/mL.
About 1 to 3 weeks of treatment are required before therapeutic effectiveness becomes apparent. The most
frequent side effects are those attributable to anticholinergic effects: dry mouth, constipation, dizziness,
tachycardia, palpitations, blurred vision, and urinary retention. These occur at blood concentrations in
excess of 300 ng/mL, although they may occur at therapeutic concentrations in the early stage of therapy.
Cardiac toxicity (first-degree heart block) is usually associated with blood concentrations in excess of 300
ng/mL.
Useful For: Monitoring serum concentration during therapy Evaluating potential toxicity The test may
also be useful to evaluate patient compliance
Interpretation: Most individuals display optimal response to desipramine with serum levels of 100 to
300 ng/mL. Some individuals may respond well outside of this range, or may display toxicity within the
therapeutic range; thus, interpretation should include clinical evaluation. Risk of toxicity is increased with
levels > or =300 ng/mL.
Reference Values:
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