Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FIBR
8482
FBC
80333
number of acquired conditions can result in an increase in its plasma level: -Acute or chronic
inflammatory illnesses -Nephrotic syndrome -Liver disease and cirrhosis -Pregnancy or estrogen
therapy -Compensated intravascular coagulation The finding of an increased level of fibrinogen in a
patient with obscure symptoms suggests an organic rather than a functional condition. Chronically
increased fibrinogen has been recognized as a risk factor for development of arterial thromboembolism.
Useful For: Detecting increased or decreased fibrinogen (factor I) concentration of acquired or
congenital origin Monitoring severity and treatment of disseminated intravascular coagulation and
fibrinolysis
Interpretation: This kinetic assay assesses levels of functional (clottable) fibrinogen (see Cautions).
Reference Values:
Males: 200-375 mg/dL
Females: 200-430 mg/dL
In normal, full-term newborns and in healthy, premature infants (30-36 week gestation), fibrinogen is
near adult levels and reaches adult levels by < or =21 days postnatal.
Clinical References: 1. Dang CV, Bell WR, Shuman M: The normal and morbid biology of
fibrinogen. Am J Med 1989;87:567-576 2. Bowie EJW, Owen CA Jr: Clinical and laboratory diagnosis of
hemorrhagic disorders. In Disorders of Hemostasis. Edited by OD Ratnoff, CD Forbes. Philadelphia, WB
Saunders Company, 1991, pp 68-69 3. Martinez J: Quantitative and qualitative disorders of fibrinogen. In
Hematology: Basic Principles and Practice. Edited by R Hoffman, EJ Benz Jr, SJ Shattil, et al. New York,
Churchill Livingstone, 1991, pp 1342-1354 4. Mackie IJ, Kitchen S, Machin SJ, Lowe GD: Haemostais
and Thrombosis Task Force of the British Committee for standards in Haematology. Guidelines for
fibrinogen assays. Br J Haemotol 2003;121:396-304
Fibroblast Culture
Clinical Information: Cultures of skin fibroblasts may be helpful in diagnosing many of the
lysosomal storage disorders such as the sphingolipidoses or mucopolysaccharidoses. In addition,
numerous assays including those for genetic disorders of collagen, DNA repair, fatty acid oxidation, and
pyruvate metabolism can be diagnosed using fibroblasts. Cells from skin biopsies can be put in culture at
Mayo Clinic and sent to laboratories involved in these specialized tests. Cells can also be frozen for future
studies and DNA diagnostic procedures.
Useful For: A preliminary step in obtaining material for the diagnosis of many lysosomal storage
disorders and other genetic abnormalities
Interpretation: In the rare event that the biopsy fails to result in fibroblastic outgrowth, the client will
be informed as soon as possible. Both laboratory and clinical contacts are available to help with test
selection
Reference Values:
Not applicable
Clinical References: Paul J: Cell & Tissue Culture. 5th edition. New York, Churchill Livingstone,
1975
Fibroblast Culture for Genetic Testing
Clinical Information: Fibroblast cells may be used to perform a wide range of laboratory tests. Prior
to testing, the tissue may need to be cultured to obtain adequate numbers of cells.
Useful For: Producing fibroblast cultures that can be used for genetic analysis Once confluent flasks
are established, the fibroblast cultures are sent to other laboratories, either within Mayo Clinic or to
external sites, based on the specific testing requested. This test should be used when the specimen is
chorionic villi or when cytogenetic testing is needed. For other specimen types and any other genetic
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