Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

81444
FADV
91728
Performance characteristics for specimen types other than pleural or peritoneal are unknown. Reference
ranges have not been established.
Test Performed by: University of Minnesota Physicians Outreach Laboratory
420 Delaware St. S.E.
Minneapolis, MN 55455
Adenovirus (ADV) Detection by In Situ Hybridization
Clinical Information: Adenovirus is a double-stranded DNA virus from the adeno family which
causes infections of upper and lower respiratory tract, conjunctivitis, and diarrhea. Adenovirus
pneumonia with a necrotizing bronchitis and bronchiolitis is relatively uncommon in healthy
individuals, but may be seen in immunocompromised patients. The incidence of adenovirus pneumonia
is highest in bone marrow transplantation recipients, intermediate in liver transplantation recipients, and
lowest in renal transplantation recipients. Once pneumonia develops, the infection tends to disseminate
and the mortality is 60% to 80%. In some cases in situ hybridization may be helpful to distinguish
between adenovirus and cytomegalovirus infections.
Useful For: Suspected cases of adenovirus infection
Interpretation: A positive test is indicated by blue nuclear staining. The results of these tests should
be interpreted with the positive and negative controls along with the other special stains and histologic
examination of the hematoxylin and eosin sections.
Reference Values:
This test, when not accompanied by a pathology consultation request, will be answered as either
positive or negative.
If additional interpretation/analysis is needed, please request 5439 Surgical Pathology Consultation
along with this test.
Clinical References: 1. Ohori NP, Michaels MG, Jaffe R, et al: Adenovirus pneumonia in lung
transplant recipient. Hum Pathol 1995;26:1073-1079 2. Hierholzer JC: Adenovirus in the
immunocompromised host. Clin Microbiol Rev 1992;5:262-274 3. Zarraga AL, Kerns FT, Kitchen LW:
Adenovirus pneumonia with severe sequelae in an immunocompetent adult. Clin Infect Dis
1992;15:712-713 4. Shields AF, Hackman RC, Fife KH, et al: Adenovirus infections in patients
undergoing bone-marrow transplantation. N Engl J Med 1985;312:529-533 5. Michaels MG, Green M,
Wall ER, Starzl TE: Adenovirus infection in pediatric liver transplant recipients. J Infect Dis
1992;165:170-174
Adenovirus Antibody, Serum
Reference Values:
Reference Range: or =1:64 are indicative of recent or current
infection. Titers of 1:8-1:32 may be indicative of either past or
recent infection, since CF antibody levels persist for only a few
months. A four-fold or greater increase in titer between acute and
convalescent specimens confirms the diagnosis.
Test Performed By: Focus Diagnostics, Inc.
5785 Corporate Ave.
Cypress, CA 90630-4750
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 57