Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

GLICP
89369
Females
1 month-17 years: 25.8-68.0%
18-25 years: 6.4-51.0%
26-55 years: 6.4-41.7%
> or =56 years: 6.4-27.7%
Reference values have not been established for patients that are 70 years of age.
CD4 RTE ABSOLUTE
Males
1 month-17 years: 50.0-926.0 cells/mcL
18-70 years: 42.0-399.0 cells/mcL
Reference values have not been established for patients that are 70 years of age.
Females
1 month-17 years: 170.0-1,007.0 cells/mcL
18-70 years: 42.0-832.0 cells/mcL
Reference values have not been established for patients that are 70 years of age.
Clinical References: 1. Hassan J, Reen DJ: Human recent thymic emigrants--identification,
expansion, and survival characteristics. J Immunol 2001;167:1970-1976 2. Kimmig S, Przybylski GK,
Schmidt CA, et al: Two subsets of naïve T-helper cells with distinct T-cell receptor excision circle
content in human adult peripheral blood. J Exp Med 2002;195(6):789-794 3. Junge S,
Kloeckener-Gruissem B, Zufferey R, et al: Correlation between recent thymic emigrants and CD31+
(PECAM-1) CD4 T-cells in normal individuals during aging and in lymphopenic children. Eur J
Immunol 2007;37:3270-3280 4. Dong X, Hoeltzle MV, Abraham RS: Evaluation of CD4 and CD8
recent thymic emigrants in healthy adults and children. Unpublished data 2008 5. Duszczyszyn DA,
Beck JD, Antel J, et al: Altered naiveCD4 and CD8 T-cell homeostasis in patients with
relapsing-remitting multiple sclerosis: thymic versus peripheral (non-thymic) mechanisms. Clin Exp
Immunol 2005;143:305-313
CD8 T-Cell Immune Competence Panel, Global
Clinical Information: CD8 T cells play an important role in the immune response to viral or
intracellular infectious agents, as well as antitumor immunity and immune surveillance. Upon
activation, CD8 T cells mediate a variety of effector functions, including cytokine secretion and
cytotoxicity. Interferon-gamma (IFN-gamma) is on of the early cytokines produced by CD8 T cells; it is
released within a few hours of activation.(1) The cytotoxic function is mediated by the contents of the
cytolytic granules.(1) Cell-surface mobilization of the cytolytic granule components, CD107a and
CD107b, also known as lysosome-associated membrane proteins LAMP-1 and LAMP-2, occurs when
CD8 T cells mediate their cytolytic function and degranulate.(2) CD8 T-cell activation occurs either
through the T-cell receptor (TCR)-peptide-Major-Histo Compatibility Complex (MHC-Complex) or by
use of a mitogen (eg, phorbol myristate acetate and the calcium ionophore ionomycin).
Mitogen-mediated activation is antigen nonspecific. Impairment of global CD8 T-cell activation (due to
inherent cellular immunodeficiency or as a consequence of over-immunosuppression by therapeutic
agents) results in reduced production of IFN-gamma and other cytokines, reduced cytotoxic function,
and increased risk for developing infectious complications. Agents associated with
over-immunosuppression include the calcineurin inhibitors (eg, cyclosporine A, FK506
[Prograf/tacrolimus], and rapamycin [sirolimus]), antimetabolites (eg, mycophenolate mofetil), and
thymoglobulin. Immunosuppression is most commonly used for allograft maintenance in solid-organ
transplant recipients, to prevent graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell
transplant patients and to treat patients with autoimmune diseases. In these settings, reducing the risk for
developing infectious complications as a result of over-immunosuppression is a clinical challenge.
Therapeutic drug monitoring (TDM) is routinely used in the transplant practice to avoid over-treatment
and to determine patient compliance. But, the levels of drugs measured in blood do not directly correlate
with the administered dose due to individual pharmacokinetic differences.(3) Furthermore, drug levels
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