Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

Results Expressed as a Percentage of CD19+ B-cells Percentage Absolute Count (Cells/mcL)
CD19+ CD27+ 4.6-49.1 9.4-136.0
CD19+ CD27+ IgM+ IgD+ 0.2-12.0 0.8-42.7
CD19+ CD27+ IgM- IgD- 1.9-30.4 5.2-74.2
CD19+ CD27+ IgM+ IgD- 0.3-13.1 0.8-37.8
CD19+ IgM+ 32.8-82.6 46.0-596.0
CD19+ CD38+ IgM- 2.9-51.8 8.2-275.1
CD19+ CD38+ IgM+ 7.6-48.6 14.2-229.6
CD19+ CD21+ 94.5-99.8 89.4-780.1
CD19+ CD21- 0.2-5.5 0.9-25.5
B-Cell Subset Adult Reference Values (n=96)
Results Expressed as a Percentage of Total Lymphocytes Percentage Absolute Count (Cells/mcL)
CD19+ 2.8-17.4 90.0-539.0
CD19+ CD20+ 3.2-16.8 95.0-580.8
Results Expressed as a Percentage of CD19+ B Cells Percentage Absolute Count (Cells/mcL)
CD19+ CD27+ 6.3-52.8 18.0-145.0
CD19+ CD27+ IgM+ IgD+ 1.7-29.3 4.0-85.0
CD19+ CD27+ IgM- IgD- 2.3-26.5 7.0-61.0
CD19+ CD27+ IgM+ IgD- 0-5.3 0-12.0
CD19+ IgM+ 26.0-78.0 37.0-327.0
CD19+ CD38+ IgM- 4.1-42.2 7.0-153.0
CD19+ CD38+ IgM+ 1.2-50.7 2.0-139.4
CD19+ CD21+ 92.1-99.6 85.0-533.0
CD19+ CD21- 0.2-8.6 0.3-22.0
Clinical References: T- and B-Cell Quantitation by Flow Cytometry: 1. Carmichael KF, Abayomi
A: Analysis of diurnal variation of lymphocyte subsets in healthy subjects and its implication in HIV
monitoring and treatment. 15th Intl Conference on AIDS, Bangkok, Thailand, 2004, Abstract B11052 2.
Dimitrov S, Benedict C, Heutling D, et al: Cortisol and epinephrine control opposing circadian rhythms
in T-cell subsets. Blood 2009;113(21):5134-5143 3. Dimitrov S, Lange T, Nohroudi K, Born J: Number
and function of circulating antigen presenting cells regulated by sleep. Sleep 2007;30:401-411 4.
Kronfol Z, Nair M, Zhang Q, et al: Circadian immune measures in healthy volunteers: relationship to
hypothalamic-pituitary-adrenal axis hormones and sympathetic neurotransmitters. Psychosom Med
1997;59:42-50 5. Malone JL, Simms TE, Gray GC, et al: Sources of variability in repeated T-helper
lymphocyte counts from HIV 1-infected patients: total lymphocyte count fluctuations and diurnal cycle
are important. J AIDS 1990;3:144-151 6. Paglieroni TG, Holland PV: Circannual variation in
lymphocyte subsets, revisited. Transfusion 1994;34:512-516 Immune Assessment B Cell Subsets,
Blood: 1. Warnatz K, Denz A, Drager R, et al: Severe deficiency of switched memory B cells (CD27+
IgM- IgD-) in subgroups of patients with common variable immunodeficiency: a new approach to
classify a heterogeneous disease. Blood 2002;99:1544-1551 2. Brouet JC, Chedeville A, Fermand JP,
Royer B: Study of the B cell memory compartment in common variable immunodeficiency. Eur J
Immunol 2000;30:2516-2520 3. Wehr C, Kivioja T, Schmitt C, et al: The EUROclass trial: defining
subgroups in common variable immunodeficiency. Blood 2008;111:77-85 4. Alachkar H, Taubenheim
N, Haeney MR, et al: Memory switched B-cell percentage and not serum immunoglobulin
concentration is associated with clinical complications in children and adults with specific antibody
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