Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

SDEX
9180
HGB_Q
8581
3-5 months: 1.6-42.2%
6-8 months: 0.0-16.7%
9-12 months: 0.0-10.5%
13-17 months: 0.0-7.9%
18-23 months: 0.0-6.3%
> or =24 months: 0.0-0.9%
HEMOGLOBIN S
All ages: 0.0%
Clinical References: 1. The Management of Sickle Cell Disease. 4th edition. Bethesda, MD:
National Institutes of Health. National Heart, Lung, and Body Institute, 2002 2. Rosse WF, Telen M,
Ware R: Transfusion Support for Patients with Sickle Cell Disease. Bethesda, MD: American
Association of Blood Banks. 1998 3. Ferster A, Tahriri P, Vermylen C, et al: Five years of experience
with hydroxyurea in children and young adults with sickle cell disease. Blood 2001;97:3268-3632 4.
Charache S, Terrin ML, Moore RD, et al: Effect of hydroxyurea on the frequency of painful crises in
sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N
Engl J Med 1995;332:1317-1322
Hemoglobin S, Screen, Blood
Clinical Information: Homozygous hemoglobin S (sickle cell disease) is a serious chronic
hemolytic anemia most commonly found in those of African or Middle Eastern descent. Hemoglobin S
is freely soluble when fully oxygenated; when oxygen is removed, polymerization of the abnormal
hemoglobin occurs, forming tactoids that are rigid and deformed cells. This leads to sickling of the
cells, hemolysis, and many other complications. Heterozygous hemoglobin S (sickle cell trait) is the
most common hemoglobinopathy in the United States. This condition is present in about 8% of African
Americans. Usually, hemoglobin S trait exhibits no clinical or hematological effects. A small fraction of
people with sickle cell trait have recurrent hematuria.
Useful For: Screening for hemoglobin S (sickle cell trait)
Interpretation: A positive result should be followed by hemoglobin electrophoresis to confirm the
presence and concentration of hemoglobin S.
Reference Values:
Negative
Precautions: The procedure does not distinguish hemoglobin S trait from homozygous sickle cell
disease nor any of the following combinations: S/C, S/D, S/G, S/E, S/thalassemia, S/O-Arab, S/New
York and C-Georgetown trait (Hb C-Harlem).
Clinical References: Fairbanks VF, Klee GG: Biochemical Aspects of Hematology. In Tietz
Textbook of Clinical Chemistry, 3rd edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB
Saunders Company, 1999; pp 1670-1673
Hemoglobin, Qualitative, Urine
Clinical Information: Free hemoglobin (Hgb) in urine usually is the result of lysis of RBCs present
in the urine due to bleeding into the urinary tract (kidney, ureters, bladder). Less commonly,
intravascular hemolysis (eg, transfusion reaction, hemolytic anemia, paroxysmal hemoglobinuria) may
result in excretion of free Hgb from blood into urine. Injury to skeletal or cardiac muscle results in the
release of myoglobin, which also is detected by this assay. Conditions associated with myoglobinuria
include hereditary myoglobinuria, phosphorylase deficiency, sporadic myoglobinuria, exertional
myoglobinuria in untrained individuals, crush syndrome, myocardial infarction, myoglobinuria of
progressive muscle disease, and heat injury.
Useful For: Screening for hematuria, myoglobinuria, or intravascular hemolysis
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