Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

CRP
9731
HSCRP
82047
Adults 24 h: 37 - 113
Overnight fasting: 10 - 50
3 h post prandial: 29 - 169
24 hr Creatinine, Urine (mg/24h)
Males 1000 - 2000
Females 800 - 1800
Creatinine, Urine (mg/dL)
Test Performed by: Esoterix Endocrinology
4301 Lost Hills Road
Calabasas Hills, CA 91301
C-Reactive Protein (CRP), Serum
Clinical Information: C-reactive protein (CRP) is 1 of the most sensitive acute-phase reactants for
inflammation. CRP is synthesized by the liver and consists of 5 identical polypeptide chains that form a
5-membered ring with a molecular weight of 120,000 daltons. CRP levels can increase dramatically
(100-fold or more) after severe trauma, bacterial infection, inflammation, surgery, or neoplastic
proliferation. CRP has been used to assess activity of inflammatory disease, to detect infections after
surgery, to detect transplant rejection, and to monitor these inflammatory processes.
Useful For: Detecting systemic inflammatory processes Detecting infection and assessing response
to antibiotic treatment of bacterial infections Differentiating between active and inactive disease forms
with concurrent infection
Interpretation: Elevated values are consistent with an acute inflammatory process.
Reference Values:
< or =8.0 mg/L
Clinical References: Tietz NW, Burtis CA, Ashwood ER: In Tietz Textbook of Clinical
Chemistry. Third edition. Edited by CA Burtis, ER Ashwood. Philadelphia, WB Saunders Company,
1999
C-Reactive Protein, High Sensitivity, Serum
Clinical Information: C-reactive protein (CRP) is 1 of the most sensitive acute-phase reactants.
Plasma CRP levels can increase dramatically (100-fold or more) after severe trauma, bacterial infection,
inflammation, surgery, or neoplastic proliferation. Measurement of CRP has been used historically to
assess activity of inflammatory disease, to detect infections after surgery, to detect transplant rejection,
and to monitor these inflammatory processes. While assays for CRP have been available for many
years, the traditional assays lack the sensitivity to measure basal levels of CRP. In the mid-1990s, more
sensitive methods for measurement of CRP were introduced. These methods, referred to as high
sensitivity CRP (hs-CRP), can accurately measure basal levels of CRP throughout the currently
accepted cardiovascular risk assessment range (0.20-10.0 mg/L). These hs-CRP assays were used to
assess outcomes in patients with unstable angina and showed that hs-CRP values in the upper tertile
(>3.0 mg/L) were associated with increased risk of developing myocardial infarction (1,2). Data from
prospective studies monitoring hs-CRP in apparently healthy populations also has been published. All
prospective studies reported to date have been positive, with adjusted relative risks of developing
cardiovascular disease or ischemic events ranging from 2.3 to 4.8 in the highest quartile or quintile of
data versus the lowest quartile or quintile (3-6). It also has been shown that hs-CRP is additive with
total cholesterol, LDL and HDL, as well as the Framingham 10-year risk score, with respect to risk
prediction (7-8). More aggressive treatment strategies may be pursued in patients determined to be at
increased risk by hs-CRP values.
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