Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

OPATM
84326
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by RA McPherson, MR Pincus. New York, WB Saunders
Company, 2007, Chapter 53, Part VI, pp 961-971
Opiate Confirmation, Meconium
Clinical Information: Opiates are naturally occurring alkaloids that are derived from the opium
poppy and demonstrate analgesic effects. Opioids are derived from natural and semisynthetic alkaloids of
opium or synthetic compounds(1): -Codeine is a naturally occurring opioid agonist often incorporated into
formulations along with acetaminophen or aspirin to increase its analgesic effect.(2) Codeine is
metabolized to morphine and subsequently undergoes glucuronidation and sulfation. -Morphine is an
opioid receptor agonist that is used for major pain analgesia.(2) It has been shown to distribute widely into
many fetal tissues,(4) and has been detected in meconium. -Hydrocodone is a semisynthetic analgesic
derived from codeine. Hydrocodone is 6 times more potent than codeine and is prescribed for treatment of
moderate-to-moderately severe pain.(2) Hydrocodone undergoes O-demethylation in vivo, forming
hydromorphone. -Hydromorphone, a semisynthetic derivative of morphine, is an opioid analgesic. It is 7
to 10 times more potent than morphine, its addiction liability is similar to morphine.(2) -Oxycodone, a
semisynthetic narcotic derived from thebaine. It is metabolized by O-demethylation, forming
oxymorphone.(2) -Oxymorphone is a semisynthetic opioid derivative of thebaine and is indicated for
moderate-to-severe pain.(2) -Heroin, a semisynthetic derivative of morphine, is rapidly deacetylated in
vivo to the active metabolite 6-monoacetlymorphine (6-MAM), which is further hydrolyzed to
morphine.(2) Opiates have been shown to readily cross the placenta and distribute widely into many fetal
tissues. Opiate use by the mother during pregnancy increases the risk of prematurity and small size for
gestational age. Furthermore, heroin-exposed infants exhibit an early onset of withdrawal symptoms
compared to methadone-exposed infants. These infants demonstrate a variety of symptoms including
irritability, hypertonia, wakefulness, diarrhea, yawning, sneezing, increased hiccups, jitteriness, excessive
sucking, and seizures. Long-term intrauterine drug exposure may lead to abnormal neurocognitive and
behavioral development as well as an increased risk of sudden infant death syndrome. The disposition of
opiates and opioids in meconium, the first fecal material passed by the neonate, is not well understood.
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1340