Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

FRTAL
88783
Suppressor Cells (CD8)
0-2 months: 560-1,700 cells/mcL*
3-5 months: 590-1,600 cells/mcL*
6-11 months: 500-1,700 cells/mcL*
12-23 months: 620-2,000 cells/mcL*
2-5 years: 490-1,300 cells/mcL*
6-11 years: 370-1,100 cells/mcL*
12-17 years: 330-920 cells/mcL*
18-55 years: 169-955 cells/mcL
>55 years: 101-839 cells/mcL
LYMPHOCYTE RATIO
H/S ratio: > or =1.0
*Shearer WT, Rosenblatt HM, Gelman RS, et al: Lymphocyte subsets in healthy children from birth
through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin
Immunol 2003;112(5):973-980
Clinical References: 1. Carmichael KF, Abayomi A: Analysis of diurnal variation of lymphocyte
subsets in healthy subjects and its implication in HIV monitoring and treatment. 15th Intl Conference on
AIDS, Bangkok, Thailand, 2004, Abstract B11052 2. Dimitrov S, Benedict C, Heutling D, et al:
Cortisol and epinephrine control opposing circadian rhythms in T-cell subsets. Blood
2009;113(21):5134-5143 3. Dimitrov S, Lange T, Nohroudi K, Born J: Number and function of
circulating antigen presenting cells regulated by sleep. Sleep 2007;30:401-411 4. Kronfol Z, Nair M,
Zhang Q, et al: Circadian immune measures in healthy volunteers: relationship to
hypothalamic-pituitary-adrenal axis hormones and sympathetic neurotransmitters. Psychosom Med
1997;59:42-50 5. Malone JL, Simms TE, Gray GC, et al: Sources of variability in repeated T-helper
lymphocyte counts from HIV 1-infected patients: total lymphocyte count fluctuations and diurnal cycle
are important. J AIDS 1990;3:144-151 6. Paglieroni TG, Holland PV: Circannual variation in
lymphocyte subsets, revisited. Transfusion 1994;34:512-516 7. Mandy FF, Nicholson JK, McDougal
JS: Guidelines for performing single-platform absolute CD4+T-cell determinations with CD45 gating
for persons infected with human immunodeficiency virus. Center for Disease Control and Prevention.
MMWR Morb Mortal Wkly Rep 2003;52:1-13 8. Centers for Disease Control: 1997 Revised guidelines
for performing CD4+ T-cell determinations in persons infected with human immunodeficiency virus
(HIV). MMWR Morb Mortal Wkly Rep 46 no. RR-2: 1997, pp 1-29 9. U.S. Department of Health and
Human Services: Recommendations for prophylaxis against Pneumocystis carinii pneumonia for adults
and adolescents infected with human immunodeficiency virus. MMWR Morb Mortal Wkly Rep 43 no.
RR-3: 1994, pp 1-21
T-Cell Acute Lymphoblastic Leukemia (T-ALL), FISH
Clinical Information: T-cell malignancies account for approximately 12% of all non-Hodgkin
lymphomas. There are several subtypes of T-cell neoplasms: T-cell acute lymphoblastic leukemia
(T-ALL), T-cell prolymphocytic leukemia (T-PLL), T-cell large granular lymphocytic leukemia
(T-LGL), anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma, and various other
cutaneous, nodal, and extranodal lymphoma subtypes. The 2 most prevalent lymphoma subtypes are
unspecified peripheral T-cell lymphoma (3.7%) and ALCL (2.4%). T-ALL is a neoplastic disorder of
lymphoblasts committed to the T-cell lineage. These malignancies comprise 15% to 20% of acute
leukemias. While half of T-ALL patients have normal chromosome studies, molecular cytogenetic
analysis can identify abnormalities including: -Cryptic deletions of CDKN2A. -Rearrangements
involving 1p32 (STIL/TAL1), 7q34 (TRB), 11q23 (MLL), and 14q11.2 (TRAD). -Chromosomal
translocations including t(5;14)(q35;q32), t(9;22)(q34;q11.2), t(10;11)(p13;q14), and various partner
genes involved with the MLL and TRAD gene loci. -Episomal amplification involving the
ABL1/NUP214 fusion gene. These abnormalities may be seen in tissues (ie, lymph nodes), as well as in
blood and bone marrow. This assay detects the common chromosome abnormalities observed in
T-ALL. A few common chromosome abnormalities are associated with specific T-cell lymphoma
subtypes, including: -inv(14)(q11q32) and t(14;14)(q11;q32) involving the T-cell leukemia/lymphoma 1
gene (TCL1A) at 14q32 -Translocations involving the ALK gene at 2p23 in ALCL -Isochromosome 7q
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