Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

HEPP
200080
Reference Values:
Reference Range: Not Detected
Hepatitis E Virus (HEV) is a major cause of enteric non-A hepatitis worldwide. HEV IgM is typically
detected within 2-4 weeks after infection, and then persists for about two months.
Test Performed By: Focus Diagnostics, Inc.
5785 Corporate Ave.
Cypress, CA 90630-4714
Hepatitis Profile, Serum
Clinical Information: Hepatitis A Hepatitis A virus (HAV) is endemic throughout the world,
occurring most commonly, however, in areas of poor hygiene and low socioeconomic conditions. The
virus, which is transmitted primarily by the fecal-oral route, is spread by close person-to-person contact
and by food- and water-borne epidemics. Outbreaks frequently occur in overcrowded situations and in
high-density institutions and centers, such as prisons and health care or day care centers. Viral spread by
parenteral contact (with blood or oropharyngeal secretions) is possible but rare, because infected
individuals are viremic for a short period of time (usually less than 3 weeks). There is little or no evidence
of transplacental transmission from mother to fetus, or of newborns contracting HAV infection during
delivery. Hepatitis B Hepatitis B virus (HBV) is a DNA virus that is endemic throughout the world. The
infection is spread primarily through percutaneous contact with infected blood products, eg, blood
transfusion, sharing of needles by drug addicts. The virus is also found in virtually every type of human
body fluid and is known to be spread through oral and genital contact. HBV can be transmitted from
mother to child during delivery through contact with blood and vaginal secretions; it is not commonly
transmitted transplacentally. After a course of acute illness, HBV persists in approximately 10% of
patients; some of these chronic carriers are asymptomatic.
Useful For: Screening to determine a patient's previous exposure and/or immunity to hepatitis A and B
Interpretation: Hepatitis A virus (HAV) infection Anti-HAV is usually almost detectable by the onset
of symptoms (15-45 days after exposure). Serological diagnosis of acute viral hepatitis A depends on the
detection of IgM antibody and its presence indicates recent exposure and the possibility to be potentially
infectious. Anti-HAV IgG rises quickly once the virus is cleared and persists for years. A positive
anti-HAV (IgG and IgM) indicates that the patient has had either a recent or past HAV infection. Hepatitis
B virus (HBV) infection Hepatitis B surface antigen (HBsAg) is the first serological marker present
following HBV infection. A positive result is diagnostic of acute or chronic hepatitis B infection and is
associated with infectivity. Hepatitis B surface antibody (anti-HBs) appears with the resolution of HBV
infection after the disappearance of HBsAg. In acute cases, HBsAg usually disappears 1 to 2 months
following the onset of symptoms. Persistence of HBsAg for more than 6 months indicates development of
either a chronic carrier state or chronic liver disease. Hepatitis B core antibody (anti-HBc) IgM can be
detected in serum shortly after the onset of symptoms and is usually present up to 6 months (ie, core
window period). Anti-HBc IgM may be the only serologic marker of a recent hepatitis B infection
detectable following the disappearance of HBsAg and prior to the appearance of anti-HBs. See Viral
Hepatitis Serologic Profiles in Special Instructions.
Reference Values:
HEPATITIS B SURFACE ANTIGEN
Negative
HEPATITIS B CORE TOTAL ANTIBODY
Negative
HEPATITIS A ANTIBODY, IgG & IgM
Negative
HEPATITIS B SURFACE ANTIBODY
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