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Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

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espond to immunization with unconjugated vaccines by approximately 3 weeks following<br />

immunization, and the concentrations of IgG antibodies to Streptococcus pneumoniae serotypes often<br />

show at least a 2-fold increase (paired sera). The number of different serotypes to which healthy adults<br />

respond is variable. The minimum serologic response necessary to identify an individual as "normal"<br />

has not been defined, either for the number of serotypes or the magnitude of response in units of<br />

concentration. Serotype-specific antibodies may persist for up to 10 years following immunization or<br />

infection.<br />

Reference Values:<br />

Serotype Normal Value<br />

1 (1) >8.2<br />

2 (2) >7.4<br />

3 (3) >6.9<br />

4 (4) >4.1<br />

5 (5) >28.8<br />

8 (8) >13.3<br />

9N (9) >16.6<br />

12F (12) >4.3<br />

14 (14) >22.9<br />

17F (17) >44.8<br />

19F (19) >16.0<br />

20 (20) >12.1<br />

22F (22) >32.4<br />

23F (23) >49.0<br />

6B (26) >15.3<br />

10A (34) >25.5<br />

11A (43) >9.7<br />

7F (51) >30.8<br />

15B (54) >12.8<br />

18C (56) >7.0<br />

19A (57) >28.1<br />

9V (68) >44.0<br />

33F (70) >7.5<br />

Clinical References: 1. Schuchat A, Robinson K, Wenger JD, et al: Bacterial meningitis in the<br />

United States in 1995. Active surveillance team. N Engl J Med 1997 October;337(14):970-976 2.<br />

Zangwill KM, Vadheim CM, Vannier AM, et al: Epidemiology of invasive pneumococcal disease in<br />

southern California: implications for the design and conduct of a pneumococcal conjugate vaccine<br />

efficacy trial. J Infect Dis 1996 October;174(4):752-759 3. Butler JC, Breiman RF, Lipman HB, et al:<br />

Serotype distribution of Streptococcus pneumoniae infections among preschool children in the United<br />

States, 1978-1994: implications for development of a conjugate vaccine. J Infect Dis 1995<br />

April;171(4):885-889 4. Butler JC, Hoffman J, Cetron MS, et al: The continued emergence of<br />

drug-resistant Streptococcus pneumoniae in the United States: an update from the Centers for Disease<br />

Control and Prevention's Pneumococcal Sentinel Surveillance System. J Infect Dis 1996<br />

November;174(5):986-993 5. Jacob GL, Homburger HA: Simultaneous Quantitative Measurement of IgG<br />

Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong>Laboratories.com Page 1640

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