Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

80199
Useful For: Cervical carcinoma and a number of infectious conditions of the female genital tract
such as herpes, Candidiasis, human papillomavirus infection, trichomonas, etc.
Interpretation: The report is an estimate of the nature of the abnormality using the Bethesda
nomenclature. Specimen adequacy is characterized as: -Satisfactory for evaluation (with quality
indicators if applicable) or -Unsatisfactory for evaluation, further subdivided as follows: - Specimen
processed and examined but unsatisfactory for evaluation of epithelial abnormality because of
inadequate cellularity, obscuring blood or inflammation, etc. - Specimen rejected because of a broken
slide, unlabeled specimen, etc. The diagnostic interpretation may include: -Negative for intraepithelial
lesion or malignancy -Atypical squamous cells of undetermined significance characterized further as
either: - Atypical squamous cells of undetermined significance or - Atypical squamous cells, cannot
exclude high grade intraepithelial lesion -Low grade squamous intraepithelial lesion, which includes
mild squamous dysplasia (cervical intraepithelial neoplasia I [CINI]) and koilocytotic changes
consistent with HPV effect. -High grade squamous intraepithelial lesion, which includes moderate
squamous dysplasia (CINII), severe squamous dysplasia (CINIII), and squamous carcinoma in situ
(CINIII) -Atypical Glandular Cells Patients with this diagnosis are at increased risk for a clinically
significant lesion including adenocarcinoma in situ, high-grade squamous intraepithelial lesion, invasive
cervical carcinoma, or endometrial carcinoma and should have appropriate clinical follow up that may
include gynecologic examination, colposcopy, or biopsy. The correlation from cytology to subsequent
histologic examination is imprecise.
Reference Values:
Satisfactory for evaluation. Negative for intraepithelial lesion.
Note: Abnormal results will be reviewed by a physician at an additional charge.
Clinical References: 1. Wright TC Jr, Cox JT, Massad LS, et al: ASCCP-Sponsored Consensus
Conference. 2001 Consensus Guidelines for the management of women with cervical cytological
abnormalities. JAMA 2002 April;287(16):2120-9 2. Solomon D, Davey D, Kurman R, et al: The 2001
Bethesda System: terminology for reporting results of cervical cytology-Consensus Statement. JAMA
2002 April;287(16):2114-9
Cervical Papanicolaou Smear, Screening without Physician
Interpretation, 2 Slides
Clinical Information: Squamous cell carcinoma of the cervix is believed to develop in progressive
stages from normal through precancerous (dysplastic) stages, to carcinoma in situ, and eventually
invasive carcinoma. This sequence is felt to develop over a matter of years in most patients. The
etiology of cervical carcinoma is unknown, but the disease is believed to be related to sexual activity
and possibly sexually transmitted viral infections such as human papilloma virus (HPV). Most cervical
carcinomas and precancerous conditions occur in the transformation zone (squamo-columnar junction),
therefore, this area needs to be sampled if optimum results are to be obtained.
Useful For: Screening for cervical carcinoma and a number of infections of the female genital tract
including HPV, herpes, Candida, and trichomonas
Interpretation: The report is an estimate of the nature of the abnormality using the Bethesda
nomenclature. Specimen adequacy is characterized as: -Satisfactory for evaluation (with quality
indicators if applicable) or -Unsatisfactory for evaluation, further subdivided as follows: -Specimen
processed and examined but unsatisfactory for evaluation of epithelial abnormality because of
inadequate cellularity, obscuring blood or inflammation, etc. -Specimen rejected because of a broken
slide, unlabeled specimen, etc. The diagnostic interpretation may include: -Negative for intraepithelial
lesion or malignancy (NIL) -Atypical squamous cells of undetermined significance (ASCUS)
characterized further as either: -Atypical squamous cells of undetermined significance or -Atypical
squamous cells, cannot exclude high grade intraepithelial lesion -Low grade squamous intraepithelial
lesion (LSIL), which includes mild squamous dysplasia (cervical intraepithelial neoplasia I [CINI]) and
koilocytotic changes consistent with HPV effect. -High grade squamous intraepithelial lesion (HSIL),
which includes moderate squamous dysplasia (CINII), severe squamous dysplasia (CINIII), and
squamous carcinoma in situ (CINIII) -Atypical Glandular Cells Patients with this diagnosis are at
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