Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

SBL
8237
CBL
81541
Useful For: Detection of antibodies in patients having blastomycosis
Interpretation: A positive result indicates that IgG and/or IgM antibodies to Blastomyces were
detected. The presence of antibodies is presumptive evidence that the patient was or is currently infected
with (or exposed to) Blastomyces. A negative result indicates that antibodies to Blastomyces were not
detected, but does not rule out infection. All specimens testing equivocal will be repeated. Specimens
testing equivocal after repeat testing should be submitted for further testing by another conventional
serologic test (eg, CBL/81541 Blastomyces Antibody by Immunodiffusion, Spinal Fluid).
Reference Values:
Negative
Clinical References: Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In Manual of
Clinical and Laboratory Immunology. Edited by NL Rose, E Conway-de Macario, JD Folds, et al.
Washington, DC, ASM Press, 1997, pp 588-589
Blastomyces Antibody by Immunodiffusion, Serum
Clinical Information: The dimorphic fungus, Blastomyces dermatitidis, causes blastomycosis.
When the organism is inhaled, it causes pulmonary disease - cough, pain, and hemoptysis, along with
fever and night sweats. It commonly spreads to the skin, bone, or internal genitalia where suppuration
and granulomas are typical. Occasionally, primary cutaneous lesions after trauma are encountered;
however, this type of infection is uncommon.
Useful For: Detection of antibodies in patients having blastomycosis
Interpretation: A positive result is suggestive of infection, but the results cannot distinguish
between active disease and prior exposure. Routine culture of clinical specimens (eg, respiratory
specimen) is recommended in cases of suspected, active blastomycosis.
Reference Values:
Negative
Clinical References: Kaufman L, Kovacs JA, Reiss E: Clinical Immunomycology. In Manual of
Clinical and Laboratory Immunology. Edited by NL Rose, E Conway-de Macario, JD Folds, et al.
Washington, DC, American Society for Microbiology, 1997, pp 588-589
Blastomyces Antibody by Immunodiffusion, Spinal Fluid
Clinical Information: The dimorphic fungus, Blastomyces dermatitidis, causes blastomycosis.
When the organism is inhaled, it causes pulmonary disease -- cough, pain, and hemoptysis, along with
fever and night sweats. It commonly spreads to the skin, bone, or internal genitalia where suppuration
and granulomas are typical. Occasionally, primary cutaneous lesions after trauma are encountered;
however, this type of infection is uncommon. Central nervous system disease is uncommon.
Useful For: Detection of antibodies in patients having blastomycosis
Interpretation: A positive result is suggestive of infection, but the results cannot distinguish
between active disease and prior exposure. Furthermore, detection of antibodies in cerebrospinal fluid
may reflect intrathecal antibody production, or may occur due to passive transfer or introduction of
antibodies from the blood during lumbar puncture. Routine fungal culture of clinical specimens (eg,
cerebrospinal fluid) is recommended in cases of suspected blastomycosis involving the central nervous
system.
Reference Values:
Negative
Clinical References: Kaufman L, Kovacs JA, Reiss E: Clinical Immunomycology. In Manual of
Clinical and Laboratory Immunology. Edited by NL Rose, E Conway-de Macario, JD Folds, et al.
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