Mayo Test Catalog, (Sorted By Test Name) - Mayo Medical ...

UNHB
9095
HAEVP
84157
Interpretation: Free hemoglobin (Hgb), in the presence of RBCs, indicates bleeding into the urinary
tract. Free Hgb, in the absence of RBCs, is consistent with intravascular hemolysis. Note: RBCs may be
missed if lysis occurred prior to analysis; the absence of RBCs should be confirmed by examining a fresh
specimen. The test is equally sensitive to hemoglobin and to myoglobin. The presence of myoglobin may
be confirmed by MYOU/9274 Myoglobin, Urine.
Reference Values:
Appearance (internal specimens only): normal
Hemoglobin: negative
RBCs (internal specimens only): 0-2 rbcs/hpf
Clinical References: Fairbanks, V.F. and Klee G.G., Textbook of Clinical Chemistry 1986, Chapter
15, p 1562
Hemoglobin, Unstable, Blood
Clinical Information: Unstable hemoglobin disease is rare and may be caused by any 1 of a large
number of hemoglobin variants. They are inherited as an autosomal dominant trait. The severity of the
disease varies according to the hemoglobin variant; there may be no clinical symptoms or the disease may
produce a mild, moderate, or severe hemolytic anemia. The stained peripheral blood smear shows
anisocytosis, poikilocytosis, basophilic stippling, polychromasia and, sometimes, hypochromia. The
reticulocyte count may be increased. Splenomegaly and Heinz bodies may also be present.
Useful For: Work-up of congenital hemolytic anemias
Interpretation: An abnormal or unstable result is indicative of a hemoglobin variant present. Other
confirmatory tests should be performed to identify the hemoglobinopathy (HBELC/81626 Hemoglobin
Electrophoresis Cascade, Blood).
Reference Values:
Normal (reported as normal [stable] or abnormal [unstable])
Clinical References: Hoyer JD, Hoffman DR: The thalassemia and hemoglobinopathy syndromes.
In Clinical Laboratory Medicine. 2nd edition. Edited by KD McMlatchey. Philadelphia, Lippincott
Williams and Wilkins, 2002, pp 866-895
Hemolytic Anemia Evaluation
Clinical Information: Hemolytic anemia (HA) is characterized by increased red cell destruction and
a decreased red cell life span. Patients have decreased hemoglobin concentration, hematocrit, and red
blood cell count. Blood smear abnormalities may include spherocytes, acanthocytes, schistocytes,
stomatocytes, polychromasia, and target cells. Osmotic fragility also is increased due to the presence of
spherocytes. HAs may be congenital or acquired. Inherited hemolytic disorders may include red cell
membrane fragmentation, red cell enzyme defects, or abnormal structure of the hemoglobin molecule in
the red cell. Examples of congenital HA include spherocytic HA and glucose-6-phosphate dehydrogenase
(G-6-PD) deficiency, which may be intermittent, often brought on by certain drugs, fava bean ingestion,
or infections. Some hemoglobinopathies also may demonstrate a hemolytic process. Examples of acquired
HA include: autoimmune HA, direct Coombs-positive HA, disseminated intravascular coagulation, and
drug-induced HA. This consultative evaluation looks for the cause of increased red cell destruction and
includes testing for hereditary spherocytosis, hemoglobinopathies, and red cell metabolism abnormalities.
Useful For: Evaluation of hemolytic anemias of obscure cause
Interpretation: An interpretive report will be provided.
Reference Values:
Definitive results and an interpretive report will be provided.
Clinical References: 1. Beutler E: Glucose-6-phosphate dehydrogenase deficiency and other
Current as of January 3, 2013 2:22 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 882